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| Product Name | Glacial Acetic Acid, ACS Grade, ≥99.7% |
| Catalog No. | ATR-SDS-0007 |
| Description | Highly purified glacial acetic acid meeting ACS specifications, used for protein precipitation, pH adjustment of chromatography mobile phases, and as an acidifying agent in biochemical extraction procedures. |
| Intended Use | Protein precipitation prior to mass spectrometry sample preparation; mobile phase modifier in reversed-phase HPLC; acidification in tryptic digestion protocols. |
| Principle / Technology | As a weak organic acid (pKa 4.76), acetic acid protonates carboxylate groups on proteins, neutralizing their charge and promoting aggregation and precipitation; in HPLC, it serves as an ion-pairing agent. |
| Detection Method | GC purity, titration, UV absorbance |
| Sample Type | Protein solutions, cell lysates, chromatography solvents, peptides for mass spectrometry |
| Performance Range / Specifications | Purity ≥99.7%; freezing point ≥15.6°C; residue after evaporation <5 ppm |
| Sensitivity / LOD | N/A |
| Specificity | N/A |
| Reaction Conditions / Protocol | For protein precipitation: add dropwise to pH 4.0–4.5; incubate 30 min on ice; centrifuge to collect precipitate. |
| Components / Formulation | Glacial acetic acid, ACS grade |
| Storage Conditions | 15–30°C; store above 17°C to prevent freezing; corrosive |
| Shelf Life | 36 months |
| Package Specifications | 500 mL, 1 L, 2.5 L |
| Product Form | Liquid, colorless to faintly yellow |
| Quality Control | Assay by acid-base titration, freezing point, residue on evaporation, heavy metals, UV absorbance |
| Key Features | ACS certified; low residue; consistent quality; suitable for LC-MS when MS-grade option selected |
For research use only, not for clinical use.
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