Preimplantation Genetic Diagnosis (PGD) Kit Development Service

Preimplantation genetic diagnosis (PGD) is a method of genetic assessment of an embryo produced via in vitro fertilization, which is performed before implantation into the uterus. It is specifically designed for patients who suffer from some genetic disorder for which the causative factor is known, including disorders associated with single genes or whole chromosomes, as well as chromosomal anomalies. Besides, PGD technology will be important for carrying out prenatal genetic diagnosis on zygotes after performing genome modification in the future.

Alta DiagnoTech focuses on offering clients professional capabilities in developing preimplantation genetic diagnosis kits. We are able to devise suitable testing and diagnosis kits for different hereditary diseases accurately, thus assisting clients in realizing precision medicine in reproductive health.

The Significance of Preimplantation Genetic Diagnosis

PGD has many important significances, mainly reflected in the following points:

Reducing the risk of hereditary diseases.
Reducing the risk of miscarriage.

Improving the success rate of assisted reproduction.
Avoiding the dilemma of prenatal diagnosis.

Preimplantation Genetic Diagnosis (PGD) Kit Development Solutions

Our PGD kit development services are based on the detection purpose, technology type, and sample type.

Services by Test Purpose

Types	Details	Technologies
Single Gene Hereditary Disease Detection Kits	This kit is used for embryo screening for specific single-gene hereditary diseases (thalassemia, cystic fibrosis, spinal muscular atrophy, etc.).	PCR (conventional PCR, quantitative PCR, nested PCR) Digital PCR (ddPCR) Next-Generation Sequencing (NGS, such as targeted region sequencing) Short Tandem Repeat (STR) Linkage Analysis
Chromosomal Abnormality Detection Kits	This kit is used for screening embryos for aneuploidy (such as trisomy 21, trisomy 18) and chromosomal structural abnormalities (such as translocations, deletions).	Fluorescence In Situ Hybridization (FISH, suitable for partial chromosome screening) Microarray Comparative Genomic Hybridization (aCGH) Single Nucleotide Polymorphism Microarray (SNP array) High-Throughput Sequencing (NGS, such as low-depth whole-genome sequencing)
Comprehensive PGD Kits	This kit can simultaneously detect single-gene diseases and chromosomal abnormalities and is suitable for high-risk couples (e.g., advanced age, recurrent miscarriage, family history of hereditary diseases).	Next-generation Sequencing (NGS, such as whole genome sequencing or target region sequencing combined with CNV analysis) SNP Array + PCR Verification

Services by Technologies

Types	Details	Technologis
PCR-based Kits	This kit is cost-effective and suitable for the rapid detection of known single-gene mutations.	Conventional PCR Fluorescent Quantitative PCR (qPCR) Digital PCR (ddPCR, enhancing single-cell detection sensitivity)
Microarray Chip Kits	This kit enables high-throughput detection of chromosomal abnormalities across the entire genome.	aCGH (array-based comparative genomic hybridization) SNP array (single-nucleotide polymorphism array)
NGS-based Kits	Based on high precision and high throughput, this kit can simultaneously detect single-gene disorders and chromosomal abnormalities.	Targeted Sequencing (Panel-based NGS) Low-Depth Whole-Genome Sequencing (WGS) Whole-Exome Sequencing (WES, less commonly used for PGD)

Services by Sample Types

Types	Details
Cleavage-stage Embryo (Day 3 Embryo) Detection Kits	This kit is suitable for biopsy of early embryos (6-8 cell stage) and requires high-sensitivity technology (such as ddPCR, NGS).
Blastocyst Trophoblast Cells (Day 5-6 embryo) Detection Kits	This kit is suitable for blastocyst-stage biopsies, which involve larger sample volumes and can be detected using aCGH, SNP array, or NGS.

About Us

Employing cutting-edge technology and drawing from years of industry experience, we offer customized PGD kit solutions to clients with specific needs, meticulously crafted from gene testing probe design and primer optimization through kit performance verification. Using the newest techniques in molecular diagnostics, our PGD kits accurately and rapidly detect chromosomal abnormalities and single-gene hereditary diseases in embryos, enabling greater diagnostic precision and efficiency for reproductive medicine laboratories.

Process

Service process for the development of preimplantation genetic diagnosis (PGD) kits.

With extensive experience in molecular diagnostics and in vitro diagnostics, Alta DiagnoTech provides clients with high-quality, high-precision diagnostic kit development services. If you have any related needs, please feel free to contact us.