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| Product Name | 2,2,2-Trifluoroethanol (TFE), ≥99% |
| Catalog No. | ATR-SDS-0005 |
| Description | A fluorinated alcohol solvent with strong hydrogen-bond donating properties, used to induce and stabilize secondary structure in peptides and proteins for NMR spectroscopy and circular dichroism studies. |
| Intended Use | Inducing alpha-helical conformation in peptides for structural biology studies; dissolving hydrophobic peptides and membrane proteins; solvent component in protein aggregation studies. |
| Principle / Technology | TFE strengthens intra-chain hydrogen bonds in peptides while weakening hydrophobic interactions, shifting the conformational equilibrium toward alpha-helical structures. |
| Detection Method | GC purity, circular dichroism validation of peptide helicity induction |
| Sample Type | Synthetic peptides, membrane proteins, amyloidogenic peptides, intrinsically disordered proteins |
| Performance Range / Specifications | Purity ≥99%; induces >60% alpha-helical content in model helical peptides at 50% v/v |
| Sensitivity / LOD | N/A |
| Specificity | N/A |
| Reaction Conditions / Protocol | Prepare aqueous TFE mixtures at desired concentration; typical range 20–80% TFE; incubate peptide for 30 minutes before CD measurement. |
| Components / Formulation | 2,2,2-Trifluoroethanol, anhydrous, in amber glass |
| Storage Conditions | 15–30°C, protect from light and moisture |
| Shelf Life | 24 months |
| Package Specifications | 25 mL, 100 mL |
| Product Form | Liquid |
| Quality Control | GC purity, water content, UV absorbance, NMR spectrum |
| Key Features | Standard for peptide helicity studies; anhydrous; packaged in amber glass for light protection; NMR grade available |
For research use only, not for clinical use.
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