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| Product Name | Recombinant RNase A Solution (DNase-Free) |
| Catalog No. | IVDRM-0189 |
| Description | Recombinant RNase A (Ribonuclease A) is a non-specific endoribonuclease engineered from the bovine pancreas enzyme by protein engineering and produced by yeast expression followed by purification. Because it is a recombinant product, it is free of animal-derived components and contains no bacterial endotoxin associated with prokaryotic expression. Functionally, RNase A hydrolyzes the phosphodiester bond between the 5'-ribose of a nucleotide and the phosphate group attached to the 3'-ribose of an adjacent pyrimidine nucleotide. The resulting 2',3'-cyclic phosphate intermediate is further hydrolyzed to the corresponding 3'-nucleoside phosphate, so the enzyme degrades single-stranded RNA specifically at cytidine (C) and uridine (U) residues. RNase A is exceptionally stable and shows high activity against single-stranded RNA. This product is widely used to remove RNA contamination from DNA or protein samples, and it is free of endodeoxyribonuclease, exodeoxyribonuclease, and protease contamination. |
| Intended Use | Widely used for removing RNA contamination from DNA or protein samples. |
| Principle / Technology | RNase A is an endoribonuclease that hydrolyzes the phosphodiester bond between the 5'-ribose of a nucleotide and the phosphate group on the 3'-ribose of an adjacent pyrimidine nucleotide, generating a 2',3'-cyclic phosphate that is subsequently hydrolyzed to the corresponding 3'-nucleoside phosphate. It therefore degrades single-stranded RNA specifically at C and U residues. The enzyme is produced by yeast expression and purification, free of bacterial endotoxin from prokaryotic expression systems. |
| Sample Type | DNA samples and protein samples requiring removal of RNA contamination. |
| Performance Range / Specifications | Highly active against single-stranded RNA Free of DNA and RNA residues, DNase residues, and protease residues Animal-origin-free recombinant product Expressed and purified from yeast; free of bacterial endotoxin Excellent stability |
| Specificity | Specifically cleaves single-stranded RNA at cytidine (C) and uridine (U) nucleotide residues; exhibits high activity on single-stranded RNA. |
| Components / Formulation | Recombinant RNase A supplied as a ready-to-use liquid; yeast-expressed and purified. |
| Storage Conditions | Store at -25 to -15°C. |
| Shelf Life | 1 year when stored at -25 to -15°C. |
| Package Specifications | 1 mL; 5 mL; 10 mL |
| Product Form | Liquid solution |
| Quality Control | Free of endodeoxyribonuclease and exodeoxyribonuclease contamination; free of protease contamination; free of DNA and RNA residues. |
| Source / Origin | Engineered from the bovine pancreas enzyme by protein engineering; recombinantly expressed in yeast and purified. Animal-origin-free; free of bacterial endotoxin from prokaryotic expression. |
| Expiration Date / Stability | RNase A is exceptionally stable. Valid for 1 year when stored at -25 to -15°C. |
For research use only, not for clinical use.
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