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| Product Name | DddB DNA Cytosine Deaminase |
| Catalog No. | IEC-HMM-0114 |
| Description | A broad-activity double-stranded DNA cytosine deaminase for conversion-based chromatin accessibility and transcription factor footprinting workflows. |
| Intended Use | Epigenetic research, chromatin accessibility analysis and transcription factor footprinting. |
| Principle / Technology | The enzyme converts cytosine to uracil in accessible double-stranded DNA with low dependence on neighboring sequence context. |
| Detection Method | Sequencing-based cytosine-conversion and footprint analysis. |
| Sample Type | Prepared chromatin, nuclei or DNA substrates used in deaminase footprinting methods. |
| Performance Range / Specifications | 20 µg or 80 µg packages. |
| Specificity | Broad double-stranded DNA activity with reduced neighboring-sequence preference supports more uniform conversion. |
| Reaction Conditions / Protocol | Incubate the prepared substrate with the enzyme under an optimized deamination condition, terminate the reaction and proceed to library preparation and sequencing. |
| Components / Formulation | Purified DddB DNA cytosine deaminase solution. |
| Storage Conditions | Store at −30 to −15°C. |
| Package Specifications | 20 µg; 80 µg. |
| Product Form | Purified enzyme solution. |
| Key Features | Broad dsDNA activity; low sequence-context dependence; suitable for high-resolution footprinting workflows. |
| Shipping Conditions | Ship at or below 0°C. |
| Compatibility | Suitable for deaminase-based chromatin accessibility and footprinting protocols. |
| Application Notes / Precautions | Optimize enzyme amount and incubation time to achieve sufficient conversion without excessive background. |
For research use only, not for clinical use.
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