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| Product Name | DddA DNA Cytosine Deaminase |
| Catalog No. | IEC-HMM-0115 |
| Description | An efficient double-stranded DNA cytosine deaminase for conversion-based transcription factor footprinting and chromatin accessibility studies. |
| Intended Use | Epigenetic research, transcription factor footprinting and chromatin accessibility analysis. |
| Principle / Technology | The enzyme converts accessible cytosines in double-stranded DNA to uracil, enabling sequencing-based discrimination between protected and exposed DNA regions. |
| Detection Method | Sequencing-based cytosine-conversion and footprint analysis. |
| Sample Type | Prepared chromatin, nuclei or double-stranded DNA substrates. |
| Performance Range / Specifications | 20 µg or 80 µg packages. |
| Specificity | Preferential conversion of accessible DNA supports localization of protein-protected footprints. |
| Reaction Conditions / Protocol | Treat the prepared substrate under optimized deamination conditions, stop the reaction and proceed with library preparation and sequencing. |
| Components / Formulation | Purified DddA DNA cytosine deaminase solution. |
| Storage Conditions | Store at −30 to −15°C. |
| Package Specifications | 20 µg; 80 µg. |
| Product Form | Purified enzyme solution. |
| Key Features | Efficient dsDNA cytosine conversion; suitable for high-resolution footprinting; compatible with sequencing-based epigenetic analysis. |
| Source / Origin | Derived from a bacterial toxin-associated cytosine deaminase system. |
| Shipping Conditions | Ship at or below 0°C. |
| Compatibility | Suitable for deaminase-based chromatin accessibility and transcription factor footprinting protocols. |
| Application Notes / Precautions | Optimize reaction time, enzyme amount and substrate accessibility for each assay format. |
For research use only, not for clinical use.
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