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| Product Name | Ultra-Low Residual Heat-Labile Uracil DNA Glycosylase (UDG/UNG) (1 U/uL) |
| Catalog No. | IVDRM-0576 |
| Description | A heat-labile uracil-DNA glycosylase that hydrolyses the N-glycosidic bond between uracil and the sugar-phosphate backbone of uracil-containing DNA, releasing free uracil. Unlike an ordinary UDG, the heat-labile enzyme leaves no residual activity that would attack dU-containing amplicons once inactivated, and this format is put through an ultra-low residual manufacturing process that holds E. coli host DNA below 0.1 copies per unit for pathogen detection and molecular diagnostics. The enzyme is fully inactivated by 10 minutes at 50°C, 5 minutes at 55°C or 5 minutes at 95°C, 0.05 U per reaction digests 100,000 copies of dU-DNA template, and 2 U in a 20 uL reaction does not inhibit RT-qPCR. Purity is at least 95% with no exonuclease, nickase or RNase residue. |
| Intended Use | dU carryover prevention and pathogen detection in PCR, RT-qPCR and molecular diagnostic workflows |
| Principle / Technology | Hydrolysis of the N-glycosidic bond of uracil in DNA with heat-labile inactivation between 50 and 95°C |
| Sample Type | dU-carrying DNA templates and amplification products |
| Specificity | Host DNA residue below 0.1 copies per unit; no exonuclease, nickase or RNase residue; inert towards RNA |
| Reaction Conditions / Protocol | Add 0.05 to 2 U per reaction to the master mix before amplification and inactivate by heating between 50 and 95°C |
| Storage Conditions | -25 to -15°C |
| Shelf Life | 2 years |
| Package Specifications | 100 U; 500 U; 10000 U |
| Key Features | Ultra-low host DNA residue for molecular diagnostics; complete inactivation at 50°C in 10 minutes |
| Purity | Greater than or equal to 95% |
| Concentration | 1 U/uL |
| Activity / Unit Definition | 0.05 U digests 100,000 copies of dU-DNA template |
| Readouts / Downstream Assays | Carryover contamination control verified by qPCR |
For in vitro diagnostic use.
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