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| Product Name | RNase R for Linear RNA Digestion and circRNA Enrichment (20 U/uL) |
| Catalog No. | IVDRM-0364 |
| Description | RNase R (ribonuclease R) is a magnesium ion dependent 3 to 5 exoribonuclease that digests essentially all linear RNA molecules while sparing circular RNA, lariat structures and double-stranded RNA with 3 overhangs shorter than seven nucleotides. It is widely used to digest linear RNA for enrichment of circular RNA or lariat RNA in gene expression and alternative splicing studies. |
| Intended Use | circRNA enrichment from biological samples; gene expression and alternative splicing studies; lariat RNA enrichment |
| Principle / Technology | Magnesium-dependent 3 to 5 exoribonucleolytic digestion of linear RNA, retaining non-linear RNA species |
| Specificity | Digests linear RNA; circular RNA, lariat RNA and short-3-overhang double-stranded RNA are largely resistant |
| Storage Conditions | Below -20°C |
| Shelf Life | 2 years |
| Package Specifications | 250 U; 2500 U; 10000 U; 1000 KU |
| Key Features | Magnesium dependent 3 to 5 exoribonuclease; high purity with no exonuclease contamination |
| Purity | >=95% (SDS-PAGE); no detectable exonuclease contamination |
| Concentration | 20 U/uL |
| Shipping Conditions | Ice pack |
For in vitro diagnostic use.
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