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| Product Name | Recombinant Ten-Eleven Translocase 2.0 with Reaction Buffer |
| Catalog No. | IVDRM-0322 |
| Description | A highly efficient single enzyme for methylation site conversion, supplied with reaction buffer. It converts methylated cytosine (5mC) specifically into uracil, and subsequent PCR translates that change into a thymine readout, enabling positive-call, single-base-resolution DNA methylation detection through C to T transitions. |
| Intended Use | Enzymatic methylation conversion ahead of library prep for DNA methylation screening and simultaneous mutation detection. |
| Principle / Technology | 5mC is oxidised and converted to uracil by the recombinant enzyme; during PCR the uracil is amplified as thymine, marking methylated positions as C to T transitions. |
| Detection Method | Methylated cytosine (5mC) across the methylome |
| Performance Range / Specifications | Input 10 to 100 ng DNA; preserves fragments up to 10 kb |
| Storage Conditions | Store at -25 to -15°C |
| Shelf Life | 1 year |
| Package Specifications | 8 T / 24 T / 96 T |
| Product Form | Recombinant enzyme supplied with reaction buffer |
| Key Features | Single-enzyme conversion chemistry; gentle on DNA compared with bisulfite treatment; compatible with standard library prep kits after conversion |
| Compatibility | Conversion products are compatible with conventional library prep kits |
For in vitro diagnostic use.
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