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| Product Name | Recombinant Human Holo-Transferrin |
| Catalog No. | RESK-0250 |
| Description | Transferrin (TF) mediates iron transport from plasma to cells. In addition to participating in respiration, cell proliferation, and regulation of the immune system, it exhibits antioxidant and bactericidal functions and is widely used in cell culture. Transferrin exists in three forms: apo-transferrin (no bound iron), holo-transferrin (bound to two iron ions), and partially saturated transferrin. Transferrin binds to specific cell-surface receptors and is internalized by endocytosis; once inside the cell, iron is released, while the apo-transferrin is recycled to the extracellular space by exocytosis without being degraded, delivering iron to cells in a safe and efficient form. This product is a recombinant human transferrin expressed and purified from Pichia pastoris using genetic recombination technology. It contains no animal-derived components, carries no risk of blood-borne viral infection, and shows high batch-to-batch consistency. This product is the holo (fully iron-saturated) form of transferrin. In addition to its iron-transport function, it serves directly as an iron source for cells, eliminating the need to add exogenous iron to the culture medium. It is commonly used in animal cell culture. |
| Intended Use | Iron-source and iron-transport supplement for serum-free and animal cell culture; the holo (iron-saturated) form supplies iron directly, so no exogenous iron needs to be added to the medium. For research use only. |
| Principle / Technology | Produced by genetic recombination technology with expression and purification from Pichia pastoris (yeast). Holo-transferrin binds specific cell-surface receptors, is internalized via endocytosis, and releases its two bound iron ions into the cell, enabling safe and efficient iron delivery. |
| Sample Type | Animal cell cultures, particularly serum-free culture systems requiring a defined iron source. |
| Performance Range / Specifications | Source: Pichia pastoris, animal origin-free TSE/BSE-free; free of antibiotic contamination Production scale: up to 100-kg level, stable and reliable supply Purity: >98.0% High batch-to-batch consistency Stringent quality testing and release |
| Specificity | Holo-transferrin (iron-saturated form; bound to two iron ions). |
| Components / Formulation | Recombinant human holo-transferrin (iron-saturated); no animal-derived components. |
| Storage Conditions | Store at 2-8 °C; protect from light and moisture; keep tightly sealed and dry. |
| Shelf Life | 2 years when stored at 2-8 °C, protected from light and moisture and kept tightly sealed and dry. |
| Package Specifications | 100 mg 500 mg 1 g 5 g |
| Product Form | Powder |
| Quality Control | Stringent quality testing and release; TSE/BSE-free; free of antibiotic contamination; no risk of blood-borne viral infection. |
| Purity | >98.0% |
| Source / Origin | Recombinant human transferrin expressed in Pichia pastoris; animal origin-free. |
| Expiration Date / Stability | Valid for 2 years when stored at 2-8 °C, protected from light and moisture, tightly sealed and dry. |
| Regulatory / Compliance | TSE/BSE-free; free of antibiotic contamination. For research use only. |
| Compatibility | Suitable for serum-free animal cell culture; serves directly as the cellular iron source, so no exogenous iron supplementation of the medium is required. |
| Application Notes / Precautions | The holo (iron-saturated) form already carries two bound iron ions and can serve as the sole iron source; for media that are already iron-rich, the apo (iron-free) form is recommended instead. |
| Batch-to-Batch Consistency | High batch-to-batch consistency; 100-kg-level production scale ensures a stable and reliable supply. |
For research use only, not for clinical use.
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