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| Product Name | Medium-Salt Tolerant Broad-Spectrum Endonuclease, Pichia Expressed (250-300 U/uL) |
| Catalog No. | IVDRM-0371 |
| Description | This sequence-optimised recombinant non-specific endonuclease is expressed in the yeast Pichia pastoris. It shows optimal activity at 150 mM NaCl, with best performance between 125 and 250 mM salt, closing the gap of physiological salt conditions left by conventional and high-salt tolerant nucleases. It efficiently removes nucleic acid contamination and markedly reduces sample viscosity across production processes; in biopharmaceutical manufacturing including virus purification, vaccine production and protein or polysaccharide drug production it clears host residual nucleic acid to picogram levels, and in cell therapy and vaccine research it prevents PBMC clumping. |
| Intended Use | Nucleic acid removal under physiological salt conditions; virus purification, vaccine and protein or polysaccharide manufacturing; PBMC clumping prevention in cell therapy |
| Principle / Technology | Non-specific endonucleolytic cleavage digesting DNA and RNA, with optimal activity at 150 mM NaCl |
| Sample Type | Cell supernatants; cell lysates; virus; vaccines; protein and polysaccharide drugs; peripheral blood mononuclear cells |
| Storage Conditions | -15 to -25°C |
| Shelf Life | 2 years |
| Package Specifications | 25 KU; 50 KU; 100 KU; 1 MU (1000 KU) |
| Product Form | Sterile liquid enzyme |
| Key Features | Sequence optimised; optimal at physiological 150 mM NaCl; yeast expression system; broad application across production processes |
| Purity | >=99% |
| Concentration | 250-300 U/uL |
| Activity / Unit Definition | Optimal temperature 37°C with working range 20 to 50°C; cofactor >0.5 mM Mg2+; optimal NaCl 150 mM |
| Molecular Weight | 24.5 kDa |
| Source / Origin | Pichia pastoris expression system |
| Recommended Buffer System | 25 mM Bis-Tris, 5 mM MgCl2, 400 mM NaCl, 50% glycerol, 0.05% Tween-20, pH 7.0 |
For in vitro diagnostic use.
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