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| Product Name | L-Alanyl-L-Glutamine Dipeptide Solution, 200 mM (CAS 39537-23-0) |
| Catalog No. | RERE-0023 |
| Description | Free L-Glutamine is indispensable in culture yet awkward in liquid media: during storage and culture it spontaneously degrades and releases ammonia, which stresses cells and can interfere with protein glycosylation. The alanyl-glutamine dipeptide solves this - the peptide bond is cleaved only when the cell's own enzymes release glutamine on demand, so solutions stay stable even at high concentration and no ammonia accumulates during storage. Cells therefore receive a long-lasting, steady nutrient supply with lower decompositional toxicity, better viability and stronger growth. This ready-to-use solution is formulated at 200 mM in water for injection with 0.85% (W/V) NaCl and serves adherent and suspension mammalian cultures alike as a drop-in stabilised glutamine source. |
| Intended Use | Stabilised glutamine supplementation for adherent and suspension mammalian cell culture; reduction of ammonia accumulation in liquid media; long-duration cultures needing a steady glutamine supply. |
| Principle / Technology | Cells cleave the dipeptide intracellularly with aminopeptidases, releasing L-Glutamine only as metabolism demands it; because the stock solution is chemically stable, no spontaneous deamidation occurs and ammonia toxicity is avoided. |
| Sample Type | Sterile 200 mM aqueous solution containing 0.85% (W/V) NaCl, prepared in water for injection. |
| Performance Range / Specifications | 200 mM dipeptide concentration; highly stable in storage and in liquid media; releases glutamine only on cellular demand; lowers ammonia-related cytotoxicity; supports both adherent and suspension culture. |
| Sensitivity / LOD | Does not apply; this product induces a model rather than generating a quantifiable signal. |
| Specificity | CAS number 39537-23-0; molecular formula C8H15N3O4; molecular weight 217.22; concentration 200 mM; NaCl content 0.85% (W/V); appearance liquid. |
| Reaction Conditions / Protocol | Add to the culture medium to reach the desired working concentration and mix gently; the supplement is ready to use with no reconstitution step. |
| Components / Formulation | One bottle of 200 mM L-Alanyl-L-Glutamine solution (100 mL). |
| Storage Conditions | Store at 2-8 °C protected from light; a shelf life of 2 years applies. |
| Shelf Life | 2 years when stored as recommended. |
| Package Specifications | 100 mL per bottle |
| Product Form | Clear aqueous solution. |
| Quality Control | Released on concentration and sterility; the formulation is prepared with water for injection and checked for consistent support of cell growth. |
| Key Features | - 200 mM ready-to-use solution, no reconstitution - Releases glutamine only on cellular demand, avoiding ammonia build-up - Far more stable than free L-Glutamine in liquid media - Suits adherent and suspension mammalian cells alike |
| Purity | Solution grade; a solid-state purity figure does not apply. |
| Concentration | 200 mM L-Alanyl-L-Glutamine with 0.85% (W/V) NaCl. |
| Activity / Unit Definition | Functional performance is expressed through culture growth support rather than a numeric activity unit. |
| Molecular Weight | 217.22 |
| Source / Origin | Chemically synthesised dipeptide; no biological origin. |
| pH Range / Optimal pH | Does not apply; pH is not a meaningful specification for this product type. |
| Shipping Conditions | Shipped chilled. |
| Expiration Date / Stability | Substantially more stable than free L-Glutamine in liquid media and does not decompose to release ammonia during storage. |
| Regulatory / Compliance | Restricted to research applications; not for clinical use. |
| Compatibility | Suitable for adherent and suspension mammalian cells across common basal media. |
| Recommended Buffer System | Aqueous solution with 0.85% (W/V) sodium chloride; no separate buffer is needed. |
| Application Notes / Precautions | Avoid repeated freeze-thaw cycles; draw aliquots with sterile technique and return the bottle to 2-8 °C promptly. |
| Batch-to-Batch Consistency | Consistency between lots is maintained by concentration release testing and sterility checks. |
| Model Type | Cell culture medium supplement |
| Starting Material / Tissue Site | L-Alanyl-L-Glutamine dipeptide, 200 mM in saline |
| Delivery Standard | 100 mL bottle |
| Readouts / Downstream Assays | Cell proliferation and viability compared with free L-Glutamine-supplemented controls; ammonia accumulation as a stability marker. |
For research use only, not for clinical use.
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