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| Product Name | Heat-Labile Uracil DNA Glycosylase (UDG/UNG) (1 U/uL) |
| Catalog No. | IVDRM-0558 |
| Description | A heat-labile uracil-DNA glycosylase that catalyses hydrolysis of the N-glycosidic bond between uracil bases and the sugar-phosphate backbone of DNA strands containing uracil, releasing free uracil. Compared with regular UDG, the heat-labile enzyme avoids the residual activity that can degrade dU-containing amplification products at room temperature after inactivation, so carryover contamination control does not threaten the amplified products themselves. The enzyme works at room temperature, is temperature sensitive and easily inactivated by heating at 95°C for 5 to 10 minutes, and it supports contamination prevention in PCR and RT-qPCR workflows as well as removal of uracil bases from single or double stranded DNA. |
| Intended Use | PCR and RT-qPCR carryover and aerosol contamination prevention, and removal of uracil bases from DNA |
| Principle / Technology | Hydrolysis of the N-glycosidic bond of uracil in DNA with rapid heat inactivation at 95°C |
| Sample Type | dU-containing carryover products and DNA substrates containing uracil |
| Specificity | Heat labile at 95°C for 5 to 10 minutes; active at room temperature |
| Reaction Conditions / Protocol | Pre-treat the reaction at room temperature to degrade carryover products, then heat at 95°C to inactivate before amplification |
| Storage Conditions | -25 to -15°C |
| Shelf Life | 2 years |
| Package Specifications | 100 U; 500 U; 10000 U; 100000 U; 500000 U |
| Key Features | Room temperature activity with easy inactivation; free of exonuclease, nickase and RNase residue |
| Concentration | 1 U/uL |
| Readouts / Downstream Assays | Carryover contamination control verified by qPCR |
For in vitro diagnostic use.
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