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| Product Name | Heat-Labile dsDNase with RNase Inhibitor for Genomic DNA Removal |
| Catalog No. | IVDRM-0480 |
| Description | An endonuclease that cleaves the phosphodiester backbone of DNA to give oligonucleotides with 5 prime phosphate and 3 prime hydroxyl ends, this dsDNase digests double stranded DNA specifically and leaves single stranded DNA, primers, probes and RNA untouched. Because the enzyme is heat labile it is inactivated rapidly at 65°C, so removal of genomic DNA contamination before reverse transcription needs no separate EDTA step, saving time compared with classical DNase I treatment and helping to keep RNA quantification accurate. The formulation is supplied together with an RNase inhibitor. |
| Intended Use | Removal of genomic DNA contamination from RNA samples before reverse transcription |
| Principle / Technology | Specific endonucleolytic digestion of double stranded DNA, with rapid heat inactivation at 65°C |
| Detection Method | Reverse transcription pre-treatment for accurate RNA quantification |
| Sample Type | RNA samples; double stranded DNA contamination |
| Reaction Conditions / Protocol | Treat the RNA sample with the enzyme, then heat at 65°C to inactivate; no EDTA addition required |
| Storage Conditions | -25 to -15°C |
| Shelf Life | 2 years |
| Package Specifications | 1000 T; 50 T |
| Key Features | Heat labile at 65°C; paired RNase inhibitor; leaves RNA, primers and probes intact |
| Readouts / Downstream Assays | Genomic DNA removal verified by gel or qPCR |
For in vitro diagnostic use.
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