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| Product Name | GMP-Grade mRNA Cap 2′-O-Methyltransferase (50 U/uL) |
| Catalog No. | IVDRM-0347 |
| Description | A recombinant vaccinia virus protein expressed in E. coli, this methyltransferase adds a methyl group at the 2′-O position of the first nucleotide beside the cap on the 5′ end of RNA. Drawing on SAM as the methyl donor, it converts m7GpppN-capped RNA into the Cap1 architecture that raises translation efficiency and improves expression in mRNA transfection and microinjection experiments. Manufactured under GMP process requirements and supplied as a liquid. |
| Intended Use | Cap1 modification of mRNA for vaccine and drug development; enhancement of mRNA translation efficiency in transfection and microinjection workflows. |
| Specificity | Requires m7GpppN-capped RNA as substrate; SAM serves as methyl donor |
| Storage Conditions | -25 °C to -15 °C |
| Shelf Life | 12 months |
| Package Specifications | 10000 U, 50000 U, 20 MU and 250000 U packs |
| Product Form | Liquid |
| Concentration | 50 U/uL |
| Activity / Unit Definition | One unit methylates 10 pmol of an 80 nt capped RNA transcript within 1 hour at 37 °C |
| Source / Origin | Recombinant vaccinia virus protein, expressed in E. coli |
| Regulatory / Compliance | GMP grade |
| Recommended Buffer System | 20 mM Tris-HCl pH 8.0, 0.1 mM EDTA, 1 mM DTT, 100 mM NaCl, 50% glycerol, 0.1% Triton X-100 |
| Model Type | Cap1 methyltransferase, GMP grade |
For in vitro diagnostic use.
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