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| Product Name | GMP-Grade High-Salt Tolerant Broad-Spectrum Endonuclease (250-300 U/uL) |
| Catalog No. | IVDRM-0370 |
| Description | This recombinant non-specific endonuclease originates from a marine microorganism and is engineered for expression in E. coli. Compared with conventional broad-spectrum nucleases it shows optimal activity at 0.5 M NaCl, fitting salt-rich process streams. It digests DNA and RNA to remove nucleic acid contamination and reduce sample viscosity, serving virus purification where it reduces AAV particle aggregation and improves virus recovery, vaccine production, and protein or polysaccharide manufacturing where it lowers host residual nucleic acid to picogram levels. It also prevents PBMC clumping in cell therapy and vaccine research. |
| Intended Use | Nucleic acid removal in high-salt bioprocess streams; virus purification with reduced AAV aggregation; vaccine and protein or polysaccharide manufacturing; PBMC clumping prevention |
| Principle / Technology | Non-specific endonucleolytic cleavage digesting DNA and RNA, with optimal activity at 0.5 M NaCl |
| Sample Type | Cell supernatants; cell lysates; virus; peripheral blood mononuclear cells |
| Storage Conditions | -15 to -25°C |
| Shelf Life | 2 years |
| Package Specifications | 25 KU; 50 KU; 100 KU; 1 MU (1000 KU); 5 MU (5000 KU) |
| Key Features | GMP grade; animal origin free and antibiotic free; drug master file filed; optimal activity at 0.5 M NaCl; sterile liquid format |
| Purity | >=99% |
| Concentration | 250-300 U/uL |
| Activity / Unit Definition | Optimal temperature 37°C with working range 0 to 42°C; cofactor 1-10 mM Mg2+ |
| Molecular Weight | 24.7 kDa |
| Source / Origin | Marine microorganism derived, expressed in E. coli |
| Shipping Conditions | Dry ice |
| Recommended Buffer System | 25 mM Tris-HCl, 5 mM MgCl2, 500 mM NaCl, 50% glycerol, pH 7.5 |
For in vitro diagnostic use.
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