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| Product Name | Etoposide |
| Catalog No. | RESK-0326 |
| Description | Etoposide is an antitumor reagent that acts as a topoisomerase II inhibitor (IC50 = 59.2 uM) and is commonly used as an apoptosis inducer. The typical working concentration is 5-50 uM. It is widely applied in apoptosis studies of tumor cells, including small cell lung cancer, malignant lymphoma, malignant germ cell tumors and leukemia, as well as neuroblastoma, rhabdomyosarcoma, ovarian cancer, non-small cell lung cancer, gastric cancer and esophageal cancer. |
| Intended Use | For research use as a topoisomerase II inhibitor and apoptosis-inducing agent in cell culture studies. For research use only. |
| Principle / Technology | Etoposide inhibits topoisomerase II (IC50 = 59.2 uM), stabilizing the enzyme-DNA cleavage complex and causing DNA strand breaks that trigger apoptosis. |
| Sample Type | Cultured cells (e.g., tumor cell lines) |
| Specificity | Topoisomerase II inhibitor; IC50 = 59.2 uM |
| Reaction Conditions / Protocol | Commonly used at working concentrations of 5-50 uM in cell culture; optimize concentration and treatment time for each cell type and experimental design. |
| Components / Formulation | Supplied as powder, or as a 10 mM solution in DMSO (1 mL) |
| Storage Conditions | Powder: store at -25 to -15°C. Once dissolved in solvent: store at -85 to -65°C. |
| Shelf Life | Powder: 3 years at -25 to -15°C; in solution: 2 years at -85 to -65°C |
| Package Specifications | 10 mg 100 mg 500 mg 1 g 10 mM x 1 mL in DMSO |
| Product Form | Powder (also available as 10 mM solution in DMSO) |
| Concentration | 10 mM (DMSO solution format) |
| Activity / Unit Definition | Topoisomerase II inhibition: IC50 = 59.2 uM |
| Molecular Weight | 588.56 g/mol |
| Source / Origin | CAS No. 33419-42-0 |
| Expiration Date / Stability | Powder stable for 3 years at -25 to -15°C; solutions stable for 2 years at -85 to -65°C |
| Regulatory / Compliance | For research use only |
| Compatibility | Compatible with standard cell culture workflows for apoptosis induction |
| Recommended Buffer System | Dissolve in DMSO or an appropriate solvent before dilution into cell culture medium |
| Application Notes / Precautions | Commonly used working concentration is 5-50 uM; optimize for each cell type. Applicable to apoptosis induction studies in a broad range of tumor cells, including small cell lung cancer, malignant lymphoma, malignant germ cell tumors, leukemia, neuroblastoma, rhabdomyosarcoma, ovarian cancer, non-small cell lung cancer, gastric cancer and esophageal cancer. Store stock solutions at -85 to -65°C and avoid repeated freeze-thaw cycles. |
For research use only, not for clinical use.
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