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| Product Name | Amphotericin B Solution, 10 mg/mL |
| Catalog No. | RERE-0358 |
| Description | Amphotericin B is a polyene antifungal antibiotic isolated from Streptomyces nodosus. It binds ergosterol in fungal cell membranes, changing membrane permeability so that potassium ions and amino acids leak out and normal fungal metabolism collapses. Because bacterial and viral membranes lack ergosterol, the compound leaves them untouched; cholesterol in animal cell membranes has some affinity for the drug, which accounts for its known toxicity profile. |
| Intended Use | Control of fungal and yeast contamination in cell culture and related research systems. |
| Principle / Technology | Ergosterol binding disrupts fungal membrane integrity, causing leakage of intracellular components and cell death. |
| Specificity | 10 mg/mL; CAS 1397-89-3. |
| Reaction Conditions / Protocol | Add to culture media at the working concentration appropriate for the system under study. |
| Storage Conditions | 2-8°C; protected from light; 12 months. |
| Package Specifications | 5 mL, 10 mL |
| Key Features | Polyene chemistry from Streptomyces nodosus; selective for ergosterol-containing organisms; two pack sizes. |
For research use only, not for clinical use.
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