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| Product Name | 65 µm High-Capacity Strong Anion-Exchange PMMA Medium ~140 mg/mL BSA DBC |
| Catalog No. | IGM-HMM-0245 |
| Description | The Alta DiagnoTech strong anion-exchange medium uses monodisperse, hydrophilically modified PMMA beads carrying a quaternary-ammonium ligand. The high-strength matrix combines low nonspecific adsorption with stable bed behavior, high flow capability and charge-based selectivity for large biomolecules. |
| Intended Use | Capture, intermediate purification and polishing of monoclonal antibodies, viruses, vaccines and high-molecular-weight recombinant proteins. |
| Principle / Technology | Strong anion-exchange chromatography using a quaternary-ammonium ligand on porous PMMA beads. |
| Performance Range / Specifications | Approximately 65 µm particles; ligand density approximately 0.24 meq/mL; dynamic binding capacity approximately 140 mg/mL for BSA; maximum pressure 0.5 MPa. |
| Package Specifications | 30 mL, 50 mL, 100 mL, 300 mL, 500 mL, 1 L, 5 L, 10 L, 50 L and 100 L |
| Product Form | PMMA strong anion-exchange chromatography medium |
| Key Features | Approximately 140 mg/mL BSA dynamic binding capacity Approximately 0.24 meq/mL ligand density 150-750 cm/h recommended flow 0.5 M NaOH cleaning capability |
| Product Type | Strong anion-exchange chromatography medium |
| Function / Efficacy | Charge-based purification of negatively charged biomolecules. |
| Customization | Prepacked columns are available in 7.7 × 22 mm, 16 × 25 mm and 7.7 × 100 mm formats; additional formats may be customized. |
| Functional Group | Quaternary ammonium |
| Chromatography Mode | Strong anion-exchange chromatography |
| Matrix | Polymethyl methacrylate (PMMA) |
| Particle Size | Approximately 65 µm |
| Ligand / Bonded Phase | −CH₂N⁺(CH₃)₃ |
| Dynamic Binding Capacity | Approximately 140 mg/mL for BSA |
| Ligand Density | Approximately 0.24 meq/mL |
| Maximum Operating Pressure | 0.5 MPa |
| CIP / Sanitization Conditions | 0.5 M NaOH |
| Recommended Flow Rate | 150-750 cm/h |
| pH Stability | pH 2-12 |
| Chemical Stability | Common buffers, 1 M acetic acid, 1 M NaOH, 1 M HCl, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine hydrochloride and 8 M urea; avoid strong oxidants. |
| Operating Temperature | 2-30 °C |
For research use only, not for clinical use.
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