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| Product Name | 50 µm High-Flow PS-DVB Strong Ion-Exchange Media Up to 120 mg/mL |
| Catalog No. | IGM-HMM-0287 |
| Description | Alta DiagnoTech strong cation- and anion-exchange media use uniform, open-pore PS-DVB microspheres with a hydrophilic surface. The rigid matrix combines high flow, high resolution, high capacity and low backpressure for large-scale biomolecule purification. |
| Intended Use | Separation and purification of monoclonal antibodies, viral vaccines and other biomacromolecules. |
| Principle / Technology | Strong cation or strong anion exchange on surface-functionalized, hydrophilically modified PS-DVB microspheres. |
| Performance Range / Specifications | Approximately 50 µm particles. Four variants provide about 70-120 mg/mL dynamic binding capacity, depending on ligand and test protein. |
| Storage Conditions | 20% ethanol at 4-25 °C |
| Package Specifications | 30 mL, 50 mL, 100 mL, 300 mL, 500 mL, 1 L, 5 L, 10 L, 50 L and 100 L |
| Product Form | Strong ion-exchange chromatography medium |
| Key Features | Open-pore PS-DVB matrix Strong cation and anion exchange options 300-1200 cm/h recommended flow Up to 120 mg/mL dynamic capacity |
| Product Type | Strong ion-exchange chromatography medium |
| Function / Efficacy | High-flow charge-based capture and purification of biomacromolecules. |
| Chromatography Mode | Strong cation-exchange or strong anion-exchange chromatography |
| Matrix | Monodisperse polystyrene-divinylbenzene (PS-DVB) with hydrophilic surface modification |
| Particle Size | Approximately 50 µm |
| Ligand / Bonded Phase | Sulfonate for cation exchange or trimethylammonium for anion exchange |
| Dynamic Binding Capacity | Cation-exchange variants: approximately 100 mg/mL for lysozyme or 70 mg/mL for human IgG; anion-exchange variants: approximately 80 or 120 mg/mL for BSA |
| Ligand Density | Cation-exchange variants: approximately 0.16 or 0.14 meq/mL; anion-exchange variants: approximately 0.20 or 0.25 meq/mL |
| Maximum Operating Pressure | 2.0 MPa |
| CIP / Sanitization Conditions | 1 M NaOH |
| Recommended Flow Rate | 300-1200 cm/h |
| pH Stability | pH 1-14 |
| Chemical Stability | Compatible with common buffers, 1 M acetic acid, 1 M NaOH, 1 M HCl, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine hydrochloride and 8 M urea. Avoid strong oxidants, oxidizing acids, strong reducing agents, acetone and benzyl alcohol. |
| Operating Temperature | 4-30 °C |
For research use only, not for clinical use.
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