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| Product Name | 50 µm Anti-A/Anti-B Agglutinin-Removal Affinity PMMA Media |
| Catalog No. | IGM-HMM-0232 |
| Description | The Alta DiagnoTech paired affinity media are designed to remove anti-A and anti-B agglutinin antibodies from plasma-derived immunoglobulin after upstream chromatography. Monodisperse PMMA beads carry polysaccharide antigen A or B ligands for selective binding, with low ligand leakage and low nonspecific adsorption. |
| Intended Use | Selective removal of anti-A and anti-B agglutinins from plasma-derived immunoglobulin preparations. |
| Principle / Technology | Immunoaffinity chromatography using polysaccharide antigen A and antigen B ligands on PMMA beads. |
| Performance Range / Specifications | Approximately 50 µm particles; pH range 2-12; maximum pressure 0.8 MPa; two complementary affinity media target anti-A and anti-B agglutinins. |
| Storage Conditions | 20% ethanol storage solution |
| Package Specifications | Each affinity medium: 30 mL, 50 mL, 100 mL, 300 mL, 500 mL, 1 L, 5 L, 10 L, 50 L and 100 L |
| Product Form | PMMA affinity chromatography media |
| Key Features | Selective anti-A and anti-B removal High binding capacity and low ligand leakage Low nonspecific adsorption 0.5 M NaOH cleaning capability |
| Regulatory / Compliance | Anti-A and anti-B content limit: ≤1:64. |
| Product Type | Agglutinin-removal affinity chromatography media |
| Function / Efficacy | Removal of anti-A and anti-B antibodies to improve purity and safety of plasma-derived immunoglobulin. |
| Customization | Prepacked columns are available in 7.7 × 22 mm, 16 × 25 mm and 7.7 × 100 mm formats; additional formats may be customized. |
| Chromatography Mode | Anti-A and anti-B immunoaffinity chromatography |
| Matrix | Polymethyl methacrylate (PMMA) |
| Particle Size | Approximately 50 µm |
| Ligand / Bonded Phase | Polysaccharide antigen A or antigen B |
| Dynamic Binding Capacity | High binding capacity; no numerical value stated. |
| Maximum Operating Pressure | 0.8 MPa |
| CIP / Sanitization Conditions | 0.5 M NaOH is described for effective cleaning and sanitization. |
| pH Stability | pH 2-12 |
| Chemical Stability | Common buffers, 1 M acetic acid, 1 M NaOH, 1 M HCl, 70% ethanol, 30% isopropanol, 30% acetonitrile, 1% SDS, 6 M guanidine hydrochloride and 8 M urea; avoid strong oxidants |
For research use only, not for clinical use.
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