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| Product Name | 50 µm Anion/Hydrophobic Multimode Agarose Medium 45-85 mg/mL mAb DBC |
| Catalog No. | IGM-HMM-0228 |
| Description | The Alta DiagnoTech multimode chromatography medium combines anion-exchange and hydrophobic interaction mechanisms on high-flow, high-rigidity agarose beads. Controlled pore structure and reinforced bead rigidity support high binding capacity, favorable flow performance and scale-up from laboratory to industrial purification. |
| Intended Use | Multimode chromatographic purification of monoclonal antibodies and other biomolecules in laboratory and industrial workflows. |
| Principle / Technology | Anion-exchange and hydrophobic-interaction multimode chromatography. |
| Performance Range / Specifications | 50 µm particles; 45-85 mg/mL mAb dynamic binding capacity at 4-5 minutes residence time and approximately pH 8; ion capacity 80-120 µmol/mL as Cl−; maximum pressure 0.3 MPa. |
| Storage Conditions | 20% ethanol at 4-30 °C |
| Package Specifications | 25 mL, 100 mL, 500 mL, 1 L, 5 L and 10 L |
| Product Form | Agarose chromatography medium |
| Key Features | Anion/hydrophobic multimode selectivity 45-85 mg/mL mAb dynamic binding capacity High-flow, high-rigidity agarose matrix Laboratory-to-industrial scalability |
| Product Type | Multimode chromatography medium |
| Function / Efficacy | Multimode purification using combined anion-exchange and hydrophobic interactions. |
| Customization | Prepacked columns are available in 7.7 × 22 mm, 16 × 25 mm and 7.7 × 100 mm formats; additional formats may be customized. |
| Chromatography Mode | Anion-exchange/hydrophobic interaction multimode chromatography |
| Matrix | High-flow, high-rigidity agarose beads |
| Particle Size | 50 µm |
| Ligand / Bonded Phase | Anionic ligand plus phenyl ring |
| Dynamic Binding Capacity | 45-85 mg/mL for mAb at 4-5 minutes residence time and approximately pH 8 |
| Ion Capacity | 80-120 µmol/mL as Cl− |
| Maximum Operating Pressure | 0.3 MPa |
| CIP / Sanitization Conditions | 0.5 M NaOH |
| Recommended Flow Rate | 60-300 cm/h in a 50/30 column with 10 cm bed height |
| Maximum Flow Rate | 600 cm/h at 0.1 MPa in a 26 mm ID × 15 cm bed column at 25 °C |
| pH Stability | pH 2-12 during operation; pH 2-14 during CIP |
| Chemical Stability | Common aqueous solutions, 1 M NaOH, 6 M guanidine hydrochloride, 30% isopropanol and 70% ethanol |
| Operating Temperature | 4-40 °C |
For research use only, not for clinical use.
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