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| Product Name | 40±4 µm Hydroxyapatite Multimode Media for Small to Ultra-Large Biomolecules |
| Catalog No. | IGM-HMM-0233 |
| Description | The Alta DiagnoTech hydroxyapatite chromatography media combine metal-affinity and ion-exchange behavior. Three pore-structure options support purification from small proteins through bispecific antibodies and HPV vaccines to viruses, IgM, virus-like particles and plasmids. |
| Intended Use | Multimode purification of proteins, antibodies, vaccines, viruses, IgM, virus-like particles and plasmids across three pore-size options. |
| Principle / Technology | Hydroxyapatite chromatography combining metal-affinity and ion-exchange interactions. |
| Performance Range / Specifications | Particle size 40±4 µm; bulk density 0.72 g/mL; IgG dynamic binding capacities approximately 35, 20 and 15 mg/mL for the small-, large- and ultra-large-pore variants, respectively. |
| Storage Conditions | Before opening: sealed, dry powder at 2-30 °C. After opening: 0.1 M NaOH at room temperature. |
| Package Specifications | Each pore-size variant: 10 g, 100 g, 1 kg and 5 kg |
| Product Form | Hydroxyapatite chromatography medium supplied as dry powder before opening |
| Key Features | Combined metal-affinity and ion-exchange behavior Three pore-size options 50-1,000 cm/h recommended flow Supports proteins through very large biomolecular particles |
| Product Type | Hydroxyapatite multimode chromatography medium |
| Function / Efficacy | Purification across small proteins, large antibodies and ultra-large viral or nucleic-acid assemblies. |
| Functional Group | Ca²+, PO₄³− and −OH |
| Sterilization | Autoclave at 121 °C for 20 minutes in phosphate buffer at pH 7. |
| Chromatography Mode | Hydroxyapatite metal-affinity/ion-exchange multimode chromatography |
| Matrix | Hydroxyapatite |
| Particle Size | 40±4 µm |
| Pore Size | Small-pore, large-pore and ultra-large-pore variants; numerical pore diameters not stated. |
| Dynamic Binding Capacity | Approximately 35 mg/mL, 20 mg/mL and 15 mg/mL IgG for the small-, large- and ultra-large-pore variants, respectively; tested at one-minute residence time |
| CIP / Sanitization Conditions | 1-2 M NaOH |
| Recommended Flow Rate | 50-1,000 cm/h |
| pH Stability | pH 6.5-14; the medium can be stored in 1 M NaOH for more than one year |
| Bulk Density | 0.72 g/mL |
| Regeneration Conditions | 0.4 M sodium phosphate buffer at pH 7-7.5; 1 M trisodium phosphate at pH 11-12; or 0.4-1 M potassium phosphate when higher phosphate concentration is required |
For research use only, not for clinical use.
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