| Product Name | YO-PRO-1 (Green Fluorescent Probe for Apoptotic and Necrotic Cells) |
| Catalog No. | CCAT-HMM-0041 |
| Description | YO-PRO-1, also known as oxazole yellow (Oxazole yellow), abbreviated as YP1, is a DNA green fluorescent dye that is impermeable to normal animal cell membranes but permeable to the cell membranes of apoptotic and necrotic cells. It is commonly used for the detection of apoptosis and necrosis. YO-PRO-1 is a non-membrane-permeable, high-affinity DNA-binding cyanine monomer green fluorescent dye that exhibits minimal fluorescence when unbound to DNA but emits bright green fluorescence upon binding to DNA. During apoptosis, changes in cell membrane permeability allow YO-PRO-1 to enter the cell and bind to DNA, emitting bright green fluorescence. Therefore, this fluorescent dye is often used in combination with propidium iodide (PI) for the analysis and identification of apoptotic and necrotic cells. |
| Application | YO-PRO-1 is a fluorescent probe for apoptosis detection and can be applied to most eukaryotic mammalian cells, including adherent cells and suspension cells. |
| Spectral Parameters | Ex/Em (nm) = 491/509 |
| Storage | Store at -20°C away from light. |
| Shelf Life | 1 year |
| Notes | Fluorescent dyes are prone to quenching. Please take care to avoid exposure to light to slow down fluorescence quenching. Unused probe storage solution should be stored in aliquots at -20°C to avoid repeated freeze-thaw cycles, and can be stored stably for 12 months. YP1 is irritating to the human body. Handle with care and take appropriate precautions to avoid direct contact with the skin or inhalation. For your safety and health, please wear a lab coat and disposable gloves when handling. |
For research use only, not for clinical use.
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