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| Product Name | Rapid Hi-C Library Preparation Kit |
| Catalog No. | NG-QCY-0027 |
| Description | A rapid Hi-C workflow for generating genome-wide DNA–DNA interaction libraries from cells, tissues and frozen sections. |
| Intended Use | Chromatin interaction analysis, three-dimensional genome research and genome-organization studies. |
| Principle / Technology | Crosslinked chromatin is digested, end-labeled and proximity-ligated to capture spatially associated DNA fragments for sequencing. |
| Detection Method | Hi-C next-generation sequencing and chromatin interaction analysis. |
| Sample Type | Cultured cells, animal tissues, plant tissues and compatible frozen sections. |
| Performance Range / Specifications | Input range 10,000–500,000 cells; approximately 10-hour library preparation; 2, 4 or 8 reactions; reported valid interaction pairs of at least 90% and long-range interactions above 50%. |
| Sensitivity / LOD | Supports inputs as low as approximately 10,000 cells. |
| Specificity | Proximity-ligation workflow enriches crosslinked DNA contacts for genome-wide interaction mapping. |
| Reaction Conditions / Protocol | Crosslink the sample, isolate and digest chromatin, label fragment ends, perform proximity ligation, reverse crosslinks and complete sequencing library construction. |
| Components / Formulation | Crosslink-processing, chromatin digestion, end-labeling, proximity-ligation and library preparation reagents supplied in two temperature-controlled modules. |
| Storage Conditions | Store the refrigerated module at 2–8°C and the frozen module at −30 to −15°C. |
| Package Specifications | 2 reactions; 4 reactions; 8 reactions. |
| Product Form | Two-module Hi-C library preparation kit. |
| Key Features | Approximately 10-hour workflow; low cell input; high valid-pair rate; strong long-range interaction recovery; broad sample compatibility. |
| Shipping Conditions | Ship the refrigerated module with ice packs and the frozen module at or below 0°C. |
| Compatibility | A single library is designed to support approximately 600–900 Gb of sequencing data. |
| Application Notes / Precautions | Optimize crosslinking and tissue dissociation for sample type; excessive crosslinking or damaged nuclei may reduce interaction quality. |
For research use only, not for clinical use.
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