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| Product Name | Pepstatin A, Aspartyl Protease Inhibitor |
| Catalog No. | RERE-0036 |
| Description | Pepstatin A is a highly selective inhibitor of aspartyl (acidic) proteases, binding enzymes such as pepsin, renin, cathepsins, renin-like enzymes and proteinase B in a strict one-to-one complex; it also suppresses gamma-secretase and reverse transcriptase while leaving thiol, neutral and serine proteases untouched. It is routinely paired with inhibitors of other protease classes when formulating broad-coverage cocktails for extraction work. The peptide is supplied as a white powder and dissolves in DMSO or other organic solvents. |
| Intended Use | Inhibition of acidic proteases during protein extraction; component in multi-inhibitor cocktail formulations |
| Principle / Technology | One-to-one complex formation with aspartyl proteases, occluding the active site |
| Detection Method | Pepsin, renin, cathepsins, proteinase B; also gamma-secretase and reverse transcriptase |
| Sample Type | Cell and tissue extracts requiring protection from acidic protease activity |
| Performance Range / Specifications | Typical working concentrations of 0.5 to 1.0 microgram per mL, around 1 micromolar |
| Specificity | Selective for aspartyl proteases; no inhibition of thiol, neutral or serine proteases |
| Reaction Conditions / Protocol | Prepare a 1 to 2.5 mM stock in DMSO; ensure the solvent is diluted at least 1000-fold in the final working solution |
| Components / Formulation | Pepstatin A powder, 5 mg per vial |
| Storage Conditions | 4°C for 36 months as supplied; stock solutions at -20°C |
| Shelf Life | 36 months |
| Package Specifications | 5 mg |
| Product Form | White powder |
| Quality Control | Purity at least 98% confirmed on the lot record |
| Key Features | Highly selective aspartyl protease inhibition; classic cocktail component; defined peptide sequence Isoval-Val-Val-Sta-Ala-Sta; stable powder format |
| Purity | At least 98% |
| Concentration | Stock solutions of 1 to 2.5 mM in DMSO |
| Activity / Unit Definition | Selective one-to-one inhibition of aspartyl proteases |
| Molecular Weight | 685.9 |
| Source / Origin | Chemical or fermentation-derived peptide |
| Shipping Conditions | Wet ice |
| Expiration Date / Stability | 36 months at 4°C as powder; frozen stocks for long-term keeping |
| Regulatory / Compliance | For research use only |
| Compatibility | Pairs with serine, cysteine and metalloprotease inhibitors for broad-coverage extraction cocktails |
| Application Notes / Precautions | Dissolve only in organic solvent; keep the final DMSO level in working solutions low by preparing concentrated stocks |
| Batch-to-Batch Consistency | Lot-numbered packaging; lot record retained for traceability |
| Delivery Standard | Standard catalogue shipment, packaging integrity verified before dispatch |
| Readouts / Downstream Assays | Protein extraction protected from acidic protease degradation |
For research use only, not for clinical use.
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