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| Product Name | FFPE DNA Damage Repair Reagent for NGS Library Preparation |
| Catalog No. | REKI-0085 |
| Description | A repair reagent designed for degraded formalin-fixed paraffin-embedded DNA, addressing the cytosine deamination, nicks and blocked ends that suppress library yield. Covering 5 ng to 1 ug of low-quality input, the enzyme cocktail repairs damage of varying severity and shares a single buffer with the end repair and A-tailing step of compatible library kits, so repair and library preparation run as one continuous stage. Repaired material yields roughly 10 to 200 percent more library and noticeably better mapping and error profiles at sequencing. |
| Intended Use | Repair of FFPE DNA before sequencing library preparation; improvement of library yield and read quality from degraded archival samples. |
| Principle / Technology | Enzymatic reversal of deamination, nick and blocked-end damage restores ligatable, amplifiable DNA ahead of end repair and adapter ligation. |
| Sample Type | FFPE DNA |
| Performance Range / Specifications | Input 5 ng to 1 ug; library yield improvement of roughly 10 to 200 percent; high repair efficiency on degraded templates. |
| Specificity | Single shared buffer with end repair and A-tailing systems of matching library kits. |
| Reaction Conditions / Protocol | Combine FFPE DNA with the repair mix, incubate, then proceed directly into the library construction workflow. |
| Components / Formulation | FFPE repair enzyme mix with shared reaction buffer. |
| Storage Conditions | -25 to -15 °C |
| Shelf Life | 2 years |
| Package Specifications | 8 T, 24 T, 96 T |
| Product Form | Enzyme and buffer premix |
| Key Features | Purpose-built for archival material; one-buffer integration with library kits; substantial yield recovery. |
| Starting Material / Tissue Site | 5 ng to 1 ug FFPE DNA |
| Readouts / Downstream Assays | Repaired FFPE DNA for sequencing libraries |
For research use only, not for clinical use.
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