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| Product Name | Bestatin, Aminopeptidase Inhibitor |
| Catalog No. | RERE-0040 |
| Description | Bestatin, also known as ubenimex, is a metalloprotease inhibitor targeted at aminopeptidases: it competitively blocks leucine aminopeptidase and aminopeptidase B with IC50 values of 20 and 60 nanomolar respectively, and irreversibly inhibits LTA4 hydrolase. Beyond extraction protection, published work documents immune-modulating effects, including stimulation of human bone marrow granulocyte-macrophage progenitor proliferation, direct lymphocyte stimulation through cell-surface binding, and antiproliferative activity exploited in tumour and lymphoma research. The compound is supplied as a pale white powder. |
| Intended Use | Aminopeptidase inhibition during protein extraction; immunomodulation, lymphocyte stimulation and antiproliferative research applications |
| Principle / Technology | Competitive inhibition of leucine aminopeptidase and aminopeptidase B; irreversible inhibition of LTA4 hydrolase |
| Detection Method | Leucine aminopeptidase, aminopeptidase B and LTA4 hydrolase |
| Sample Type | Cell and tissue extracts; immune-cell research systems |
| Performance Range / Specifications | IC50 of 20 nanomolar against leucine aminopeptidase and 60 nanomolar against aminopeptidase B |
| Specificity | Targeted at aminopeptidase-class metalloproteases |
| Reaction Conditions / Protocol | Dissolve in DMSO or dilute sodium hydroxide and dose according to the application protocol |
| Components / Formulation | Bestatin powder, 10 mg per vial |
| Storage Conditions | Powder at -20°C in dry conditions for 36 months |
| Shelf Life | 36 months |
| Package Specifications | 10 mg |
| Product Form | Pale white to white powder |
| Quality Control | Purity above 99% by HPLC confirmed on the lot record |
| Key Features | Dual competitive and irreversible aminopeptidase inhibition; nanomolar potency; documented immunomodulatory biology; stable powder format |
| Purity | Above 99% (HPLC) |
| Concentration | Dissolves in DMSO at 2 mM or 1 N sodium hydroxide at 50 mM; slightly soluble in water |
| Activity / Unit Definition | Competitive aminopeptidase inhibition with irreversible LTA4 hydrolase blockade |
| Molecular Weight | 308.37 |
| Source / Origin | Chemical synthesis |
| Shipping Conditions | Ambient temperature |
| Expiration Date / Stability | 36 months dry at -20°C |
| Regulatory / Compliance | For research use only |
| Compatibility | Combines with serine, cysteine and aspartyl protease inhibitors for broad-coverage extraction cocktails |
| Application Notes / Precautions | Limited aqueous solubility; prepare organic or alkaline stocks; note immunomodulatory activity when designing controls |
| Batch-to-Batch Consistency | Lot-numbered packaging; lot record retained for traceability |
| Delivery Standard | Standard catalogue shipment, packaging integrity verified before dispatch |
| Readouts / Downstream Assays | Protein extraction protected from aminopeptidase activity; immunomodulation and tumour biology research |
For research use only, not for clinical use.
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