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| Product Name | Whole blood, serum, plasma single drug assay kit, 10 ng/mL |
| Catalog No. | CD-00139 |
| Description | The whole blood, serum, plasma single drug assay kit is a specialized bioanalytical tool designed to detect specific drug components at concentrations as low as 10 ng/mL in biological samples. Suitable for use in whole blood, serum and plasma samples, the kit is easy to use and highly sensitive, ensuring accurate drug quantification in complex biological matrices. |
| Sample Type | Urine |
| Application | The product can be used to detect and quantitatively measure the concentration of a single drug in whole blood, serum and plasma samples. |
| Operating Temperature | Store at 4-30°C. |
| Transportation Condition | Transportation at room temperature. |
| Cut Off | 10 ng/mL |
In recent years, the demand for accurate and efficient drug concentration detection in biological samples has grown exponentially across multiple scientific research fields, driven by the need to understand drug pharmacokinetics, evaluate therapeutic efficacy, and ensure safety in preclinical and clinical research. Biological matrices such as whole blood, serum, and plasma are the most commonly used samples for drug analysis, as they directly reflect the presence and concentration of drugs in the human or animal body. However, these matrices present significant challenges for detection due to their complex composition—they contain a large number of proteins, lipids, and other interfering substances that can affect the accuracy and sensitivity of drug quantification.
Traditional drug detection methods, such as high-performance liquid chromatography (HPLC) without proper sample pretreatment, often struggle to achieve reliable results in complex biological matrices. Many conventional assays require tedious and time-consuming sample preparation steps, such as liquid-liquid extraction or solid-phase extraction, which not only increase the workload for researchers but also introduce potential errors during the process. Moreover, some older assay kits have relatively high detection limits (e.g., 50 ng/mL or higher), making it difficult to detect low concentrations of drugs that may still be pharmacologically active or clinically relevant.
Against this backdrop, the development of specialized assay kits tailored for whole blood, serum, and plasma samples has become a critical focus. Researchers need tools that can simplify the detection workflow while maintaining high sensitivity and specificity. The Whole Blood, Serum, Plasma Single Drug Assay Kit (Cat.No: CD-00139) is designed to address these unmet needs. With a detection limit as low as 10 ng/mL, it fills the gap in detecting low-concentration drugs in complex biological samples, supporting a wide range of research applications:
Preclinical pharmacokinetic studies: Enabling researchers to track the concentration of test drugs in animal whole blood, serum, or plasma over time, providing key data for determining drug absorption, distribution, metabolism, and excretion (ADME) profiles.
Toxicology research: Helping assess the accumulation of drugs or their metabolites in biological samples, which is essential for evaluating potential drug toxicity.
Clinical research pilot studies: Supporting preliminary investigations into drug concentration levels in human biological samples, laying the groundwork for larger-scale clinical trials.
Forensic toxicology research: Assisting in the analysis of drug residues in biological samples for research purposes related to forensic science.
The kit’s design takes into account the practical needs of research laboratories, emphasizing ease of use and compatibility with common laboratory equipment. It eliminates the need for complex and time-consuming sample pretreatment, allowing researchers to obtain accurate results with minimal hands-on time—an important advantage for labs with high sample throughput or limited technical resources.
Broad Sample Compatibility: Specifically optimized for whole blood, serum, and plasma samples, eliminating the need for researchers to purchase separate kits for different biological matrices. This compatibility ensures consistent detection performance across the most widely used sample types in drug research, reducing experimental variability.
Ultra-Low Detection Limit: Achieves a detection limit of 10 ng/mL, which is significantly lower than many conventional assay kits (which often have detection limits of 20-100 ng/mL). This low limit enables the quantification of low-concentration drugs, making it suitable for studies where drugs are present in trace amounts (e.g., early-stage metabolism studies or studies of drugs with low bioavailability).
Simplified Workflow: Requires minimal sample pretreatment—no labor-intensive steps like liquid-liquid extraction or solid-phase extraction are needed. Researchers only need to perform basic sample dilution (if required) before loading samples into the assay system, reducing the total assay time to as little as a few hours (depending on the specific detection protocol).
High Specificity: Utilizes target-specific binding reagents (e.g., monoclonal antibodies or specific probes) that selectively recognize the target drug, minimizing interference from other components in whole blood, serum, or plasma (such as proteins, lipids, or endogenous small molecules). This ensures that the detected signal accurately reflects the concentration of the target drug.
Stable Storage and Transportation: Can be stored at 4-30°C and transported at room temperature, eliminating the need for cold chain transportation and storage. This feature simplifies inventory management for laboratories and reduces the risk of kit performance degradation during shipping.
Flexible Quantification Range: While optimized for 10 ng/mL (the cut-off concentration), the kit supports a quantitative range that covers both low and moderately high drug concentrations (typically 10 ng/mL to several hundred ng/mL, depending on the specific drug). This flexibility allows it to be used in a variety of research scenarios, from detecting initial drug absorption to measuring peak drug concentrations.
Saves Time and Labor Costs: By eliminating complex sample pretreatment steps, the kit reduces the hands-on time required per sample by 50% or more compared to traditional methods (e.g., HPLC with extraction). For a laboratory processing 50 samples per week, this translates to significant time savings, allowing researchers to focus on data analysis and other high-priority tasks.
Ensures High Data Reliability: Undergoes rigorous quality control during production, with each batch tested using standard reference samples to ensure consistency in detection accuracy (typically ±5% coefficient of variation) and specificity. This reliability reduces the need for repeated experiments, lowering overall research costs and accelerating project timelines.
Reduces Experimental Errors: The simplified workflow minimizes the number of manual operation steps (e.g., transfer of extraction solvents), which are common sources of error in traditional assays. Additionally, the kit includes internal controls (where applicable) to monitor the assay process, further ensuring that any deviations are detected promptly.
Supports Diverse Research Goals: Whether used in preclinical ADME studies, toxicology testing, or clinical research pilots, the kit’s low detection limit and broad sample compatibility make it adaptable to a wide range of research objectives. This versatility means laboratories can invest in a single kit to support multiple projects, rather than purchasing multiple specialized kits.
Cost-Effective for Small to Medium Sample Sizes: The 25-test format is well-suited for laboratories with moderate sample throughput (e.g., 10-20 samples per week), avoiding the waste associated with larger kits that may expire before use. Additionally, the elimination of expensive extraction reagents (e.g., solid-phase extraction columns) further reduces per-sample testing costs.
Easy to Integrate into Existing Labs: The kit is compatible with common laboratory equipment (e.g., microplate readers for colorimetric or fluorescent detection), meaning laboratories do not need to invest in new, specialized instruments to use it. This low barrier to entry makes it accessible to both large research institutions and smaller academic labs.
For research use only, not for clinical use.
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