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| Product Name | UDP-Glucuronosyltransferase (UDPGT) Activity Assay Kit, 50T/24S |
| Catalog No. | SCAK-YJL-0173 |
| Detection Method | Visible spectrophotometry |
| Storage | Store at -20°C, 6 months |
| Intended Use | For research use only. |
| Note | For your safety and health, please wear lab coat, disposable gloves and mask during operation. |
| Product Introduction | UDP-glucuronosyltransferase (UDPGT) is a family of membrane-bound enzymes primarily located in the liver endoplasmic reticulum. They catalyze the conjugation of glucuronic acid from UDP-glucuronic acid (UDPGA) to a wide variety of lipophilic substrates, including drugs, toxins, bilirubin, and steroid hormones. This glucuronidation reaction increases substrate solubility, facilitating biliary and renal excretion, and is a major determinant of drug clearance and toxicity. This kit measures UDPGT activity by using a common substrate whose glucuronide product is detected colorimetrically. |
| Product Application | • Evaluation of hepatic drug metabolism capacity and enzyme induction/inhibition in pharmacology and toxicology. • Research on bilirubin metabolism and hyperbilirubinemia. • Studies of endobiotic (e.g., steroid hormone) conjugation and homeostasis. • Screening for environmental toxins or drugs that affect Phase II detoxification pathways. |
| Product Advantages | • Functional Activity Assay: Measures the actual conjugating activity of UDPGT enzymes, providing physiologically relevant data. • Optimized for Microsomes: Specifically designed for use with liver microsomal fractions, the native location of UDPGTs. • Direct & Convenient: Utilizes a chromogenic substrate that simplifies the detection process compared to HPLC-based methods. • Includes Critical Cofactor: Supplies the essential UDP-glucuronic acid (UDPGA) co-substrate for the reaction. |
For research use only, not for clinical use.
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