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| Product Name | Silica Magnetic Beads, 1 µm, Narrow Size Distribution for Nucleic Acid Extraction |
| Catalog No. | MAGBEA-0028 |
| Description | Monodisperse 1 µm silica-coated superparamagnetic beads with narrow size distribution (CV <10%) for high-throughput automated nucleic acid extraction. The consistent particle size ensures uniform magnetic mobility and reproducible binding/elution across all wells in 96-well and 384-well formats. Optimized silica surface chemistry provides high DNA/RNA binding capacity with low background. |
| Intended Use | Automated nucleic acid extraction on liquid handling platforms; high-throughput genomic DNA purification; viral RNA extraction; cfDNA extraction from plasma; PCR purification; NGS library cleanup. |
| Principle / Technology | Silica surface binds nucleic acids in chaotropic salt conditions (hydrogen bonding + hydrophobic interactions); magnetic separation captures bead-nucleic acid complexes; elution in low-salt buffer or water releases purified nucleic acids |
| Detection Method | Mix sample with binding buffer (chaotropic salt + isopropanol); add beads; incubate 5-10 min; magnetic separate; wash 2× with 70% ethanol; air dry; elute with TE or nuclease-free water |
| Components / Formulation | Silica-coated superparamagnetic beads (50 mg/mL suspension in water); no preservatives |
| Storage Conditions | 15-25 °C; do not freeze; keep bottle tightly closed to prevent evaporation; mix before use |
| Shelf Life | 36 months from manufacture date |
| Package Specifications | 5 mL, 25 mL, 100 mL, 500 mL suspension |
| Product Form | Dark brown-black magnetic suspension |
| Key Features | 1 µm monodisperse (CV <10%); consistent well-to-well performance; DNA binding >20 µg/mg beads; RNA binding >15 µg/mg beads; validated on KingFisher, Hamilton, Tecan, and other automated platforms; preservative-free for NGS compatibility |
| Purity | Iron content >70% (w/w) in core; silica coating thickness 20-30 nm; no detectable DNase/RNase; endotoxin <0.01 EU/mg |
| Concentration | 50 mg beads/mL suspension |
| Activity / Unit Definition | Binding capacity in µg target per mg beads as specified |
| Molecular Weight | Not applicable — inorganic/organic composite particles |
| Source / Origin | Synthetic polymer-magnetite composite; recombinant protein ligands where applicable |
| pH Range / Optimal pH | pH 6.0–9.0 working range; optimal pH varies by surface chemistry |
| Shipping Conditions | Ambient temperature; do not freeze; protect from extreme heat >40 °C |
| Expiration Date / Stability | 36 months at 15-25 °C; if beads settle, vortex >30 sec until homogeneous; do not use if beads cannot be fully resuspended |
| Regulatory / Compliance | For laboratory and research use only; RUO; preservative-free; ISO 9001 |
| Compatibility | Compatible with common chaotropic binding buffers (guanidine HCl, guanidine thiocyanate, NaI); compatible with 70-80% ethanol wash; elute in TE buffer (pH 8.0) or nuclease-free water; not compatible with >0.5% SDS in binding buffer |
| Recommended Buffer System | PBS pH 7.4 with 0.02% sodium azide or 20% ethanol for long-term storage |
| Application Notes / Precautions | Vortex thoroughly before each use; avoid drying beads; use appropriate magnetic separation times |
| Batch-to-Batch Consistency | Particle size CV ≤10%; binding capacity within ±15% of reference lot |
For research use only, not for clinical use.
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