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| Product Name | RNAlater Tissue RNA Stabilization Solution |
| Catalog No. | NATR-HMM-0149 |
| Description | An aqueous tissue storage reagent that rapidly permeates tissues to stabilize and protect cellular RNA from degradation at ambient temperature. Upon immersion, the solution inactivates endogenous RNases and precipitates RNA within intact cells, preserving the expression profile for downstream analysis. Treated samples can be stored at room temperature or refrigerated for extended periods before RNA extraction. |
| Intended Use | Immediate stabilization and preservation of RNA expression profiles in freshly collected tissue specimens prior to extraction. |
| Principle / Technology | RNase inactivation and RNA precipitation within intact tissue architecture |
| Detection Method | RNA integrity assessment by Bioanalyzer or agarose gel; downstream: RT-qPCR, RNA-Seq, microarray |
| Sample Type | Fresh animal or human tissue specimens up to 0.5 cm thickness; applicable to most solid organ and tumor tissue types |
| Performance Range / Specifications | Full thickness penetration: approximately 0.5 cm in 24 hr at room temperature |
| Sensitivity / LOD | Preserved RNA integrity (RIN ≥7) for at least 7 days at room temperature; up to 1 month at 4 °C |
| Specificity | Non-selective stabilization of all RNA species including mRNA, rRNA, miRNA, and lncRNA |
| Reaction Conditions / Protocol | Immerse tissue in 5–10 volumes of RNAlater immediately after excision; incubate overnight at 4 °C before long-term storage or direct RNA extraction |
| Components / Formulation | RNAlater solution (aqueous ammonium sulfate-based formulation |
| Storage Conditions | Room temperature; precipitates may form at low temperature but redissolve upon warming |
| Shelf Life | 24 months at room temperature |
| Package Specifications | 100 mL, 500 mL bottles |
| Product Form | Clear to slightly yellow liquid |
| Quality Control | RNA integrity preservation verified by Bioanalyzer RIN scores on mouse liver and spleen tissue after 7 days room temperature incubation |
| Key Features | Eliminates the need for immediate freezing of tissue specimens in liquid nitrogen at the collection site |
| Purity | DNase/RNase free; PCR inhibitor free; A260/A280 ≥1.8 for nucleic acid products |
| Concentration | As specified on product label; enzyme units per µL as stated |
| Activity / Unit Definition | Polymerase activity defined as nmol dNTP incorporated per 30 min per unit; other activities per product specification |
| Molecular Weight | As specified per DNA markers or protein components |
| Source / Origin | Recombinant enzymes expressed in E. coli; synthetic oligonucleotides; ultrapure reagents |
| pH Range / Optimal pH | pH 7.5–8.5 for PCR; pH 8.0 for most molecular biology applications |
| Shipping Conditions | Cold packs or dry ice for enzymes; ambient for buffers and DNA markers |
| Expiration Date / Stability | 12–24 months at –20 °C for enzymes; 12–24 months at room temperature for buffers |
| Regulatory / Compliance | Research use; ISO 13485 manufacturing for select products |
| Compatibility | Compatible with standard thermal cyclers, real-time PCR instruments, and gel electrophoresis systems |
| Recommended Buffer System | Tris-HCl, KCl, MgCl₂-based reaction buffer; TE for nucleic acid storage |
| Application Notes / Precautions | Use dedicated PCR workspace; aliquot enzymes to avoid contamination; monitor no-template controls |
| Batch-to-Batch Consistency | Enzyme activity within ±15% of reference lot; PCR performance verified with control template |
For research use only, not for clinical use.
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