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| Product Name | Magnetic Bead Circulating Cell-Free DNA Isolation Kit |
| Catalog No. | DREK-0101 |
| Description | A magnetic-bead kit for isolating cell-free DNA from cell-free liquid samples. Superparamagnetic nanoparticles and optimized binding chemistry support recovery of short cfDNA fragments and manual or automated processing. |
| Intended Use | Cell-free DNA purification for qPCR, methylation conversion and next-generation sequencing library preparation. |
| Principle / Technology | Protein digestion and selective binding of cell-free nucleic acids to superparamagnetic particles, followed by magnetic washing and elution. |
| Detection Method | qPCR, fragment analysis and next-generation sequencing. |
| Sample Type | 0.2-10 mL serum or plasma and 2-10 mL urine; other cell-free fluids may be evaluated with an optimized workflow. |
| Performance Range / Specifications | Flexible input volume; efficient recovery of short fragments; 24 samples can be processed in approximately 1 hour with a compatible 24-channel magnetic-rod extractor; 50- and 100-reaction formats. |
| Sensitivity / LOD | Designed for low-abundance cfDNA, which may occur at approximately 1-100 ng/mL in serum or plasma depending on the specimen. |
| Specificity | Optimized bead chemistry enriches short cell-free DNA while limiting recovery of high-molecular-weight genomic DNA. |
| Reaction Conditions / Protocol | Add lysis and protease reagents sequentially, bind cfDNA to magnetic particles, perform magnetic washes and elute in a reduced volume. |
| Components / Formulation | Lysis and binding reagents, protease, superparamagnetic particles, wash and elution solutions. |
| Storage Conditions | Store temperature-sensitive components at 2-8°C; protease is stable for three months at 2-8°C and should be stored at -30 to -15°C for longer periods. Store the room-temperature component set at 15-25°C. |
| Package Specifications | 50 reactions; 100 reactions. |
| Product Form | Magnetic-bead cell-free DNA extraction kit. |
| Quality Control | cfDNA yield, fragment-size profile, genomic DNA carryover and downstream sequencing performance are evaluated during release testing. |
| Key Features | 0.2-10 mL serum/plasma compatibility; 2-10 mL urine compatibility; high short-fragment recovery; no added isopropanol; manual or automated processing. |
| Shipping Conditions | Ship refrigerated components with cold packs and room-temperature components at ambient temperature. |
| Compatibility | Manual magnetic separation and compatible 24-channel magnetic-rod nucleic acid extraction instruments. |
| Application Notes / Precautions | Use properly prepared cell-free specimens and avoid premature mixing of the lysis reagent with protease, which can reduce protease activity. |
| Batch-to-Batch Consistency | cfDNA recovery and fragment-distribution performance are controlled across production batches. |
For research use only, not for clinical use.
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