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Cat.No: SM-HMM-0008 Datasheet
Specification Quantities
| Product Name | Mag COOH-600 nm |
| Catalog No. | SM-HMM-0008 |
| Description | Silicon dioxide series magnetic microspheres are specially designed for nucleic acid extraction and purification. The surface is silica material, modified with a large number of OH or COOH groups, and can bind to nucleic acids in solution through hydrophobic, hydrogen bonding and electrostatic interaction under high salt and low pH conditions, without binding with other impurities (such as proteins), and quickly separate nucleic acids from biological samples. The operation is safe and simple, which is conducive to the automation and high throughput extraction of nucleic acid. |
| Storage | Stable at 2-8°C (can be stored or transported at room temperature for short periods of time) |
| Shelf Life | 2 years |
| Average Particle Size | 450-550 nm |
| Magnetic Core | Fe3O4 |
| Shell | SiO2 |
| Magnetism Type | Superparamagnetic |
| Saturation Magnetization Strength | ~40 emu/g |
| Preservation Fluid | 20% ethanol |
| Concentration | 50 mg/mL |
Nucleic acid extraction and purification stand as foundational steps in countless scientific research endeavors, underpinning progress in fields such as molecular biology, genetics, microbiology, and biotechnology. The quality and efficiency of nucleic acid isolation directly impact the reliability of downstream experiments, including PCR amplification, sequencing, gene cloning, and gene expression analysis.
Traditional nucleic acid extraction methods, such as phenol-chloroform extraction, often suffer from notable limitations. These include complex operational procedures that demand extensive technical expertise, prolonged processing times that hinder high-throughput workflows, and the use of toxic chemical reagents that pose risks to researchers’ health and the environment. Additionally, these methods may yield nucleic acids with low purity and concentration, leading to compromised experimental results and wasted resources.
To address these challenges, magnetic microsphere-based nucleic acid extraction technology has emerged as a revolutionary solution in the research community. Magnetic microspheres offer a simplified, rapid, and efficient alternative, leveraging specific surface modifications to enable selective binding with nucleic acids. Among these advanced materials, silica-based magnetic microspheres have gained widespread recognition for their exceptional performance.
Mag COOH-600 nm is a high-performance silica-based magnetic microsphere tailored explicitly for research - grade nucleic acid extraction and purification. It integrates the advantages of silica’s strong nucleic acid-binding capacity with the superparamagnetic properties of Fe₃O₄ cores, providing researchers with a reliable tool to streamline their sample preparation processes. Designed to meet the rigorous demands of modern scientific research, this product addresses the need for consistent, high-quality nucleic acid isolation while supporting automation and high-throughput applications—critical for accelerating research progress and maximizing experimental productivity.
Core-shell structure composed of Fe₃O₄ magnetic core and SiO₂ shell, ensuring excellent magnetic responsiveness and structural stability.
Surface modified with abundant COOH groups, facilitating strong and specific binding to nucleic acids via hydrophobic, hydrogen bonding, and electrostatic interactions under high-salt and low-pH conditions.
Narrow particle size distribution (average 450-550 nm), ensuring uniform performance across all samples and minimizing experimental variability.
Superparamagnetic property enables rapid magnetic separation (within minutes) without residual magnetism, preserving nucleic acid integrity.
Stable storage at 2-8°C with a 2-year shelf life, and short-term room temperature storage/transportation capability, enhancing usability and reducing logistics constraints.
Suspended in 20% ethanol preservation fluid, preventing aggregation and maintaining microsphere activity over the product’s lifespan.
Concentration of 50 mg/mL, providing sufficient material for multiple experiments while ensuring cost-effectiveness for research laboratories.
Non-toxic and safe to operate, eliminating the need for harmful organic solvents and reducing health risks to researchers.
High nucleic acid yield and purity: Selective binding to nucleic acids (DNA/RNA) while excluding proteins, lipids, and other impurities, ensuring downstream experimental success.
Simplified workflow: Eliminates complex centrifugation or filtration steps, reducing operational complexity and shortening sample preparation time.
Compatibility with automation: Enables integration into high-throughput liquid handling systems, supporting large-scale research projects and improving experimental efficiency.
Consistent performance: Batch-to-batch stability and uniform particle size ensure reproducible results across experiments, enhancing data reliability.
Versatile application: Suitable for various biological samples, including blood, tissue, cells, saliva, and microbial cultures, meeting diverse research needs.
Easy to use: Requires minimal technical expertise, making it accessible to researchers at all skill levels and reducing training time.
Cost-effective: High concentration and long shelf life reduce per-experiment costs, optimizing research budgets for laboratories.
For research use only, not for clinical use.
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