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| Product Name | Mag COOH-5 µm |
| Catalog No. | SM-HMM-0014 |
| Description | Polymer-coated magnetic beads have rich functional COOH or NH2 groups, which are capable of covalently immobilizing biological ligands, such as peptides, proteins, antibodies and oligonucleotides. These magnetic beads can be used for immunology detection and molecular biology research. |
| Average Particle Size | 5 µm |
| Surface Group / Content | COOH (~200 µmol/g) |
| Magnetic Core | Fe3O4 |
| Shell | Polymer |
| Magnetism Type | Superparamagnetic |
| Appearance | Monodisperse |
| Preservation Fluid | 20% ethanol |
| Concentration | 10 mg/mL |
| Applications | Protein Purification Immunoassay Cell Sorting Specific Nucleic Acid Isolation Biosensors Drug Screening and Delivery |
Magnetic beads have become indispensable tools in modern biological and biomedical research, revolutionizing processes such as sample preparation, target molecule isolation, and detection. Among various types of magnetic beads, carboxyl (-COOH) functionalized magnetic beads stand out due to their versatile reactivity and ability to form stable covalent bonds with biological molecules containing amino groups (-NH2) through amide linkage reactions. This makes them a cornerstone in applications ranging from basic research to advanced analytical workflows.
The Mag COOH-5 µm magnetic beads are designed with a core-shell structure, combining the superparamagnetic properties of Fe3O4 (magnetite) with a biocompatible polymer shell. The polymer coating not only ensures the stability of the magnetic core but also provides a platform for dense carboxyl group functionalization. This structural design addresses key challenges in research, such as non-specific binding, low ligand loading capacity, and poor dispersibility, which are critical for reliable and efficient experimental results.
In recent years, the demand for high-performance magnetic beads has surged with the expansion of fields like immunology, molecular biology, and personalized medicine. Researchers require tools that offer consistent particle size, high functional group density, and excellent magnetic responsiveness to streamline workflows such as protein purification, immunoassays, and nucleic acid isolation. The Mag COOH-5 µm beads are engineered to meet these demands, serving as a reliable choice for laboratories and research institutions worldwide.
Superparamagnetic behavior enables rapid and efficient separation under an external magnetic field, with no residual magnetism after the field is removed, preventing bead aggregation and ensuring reusability.
Monodisperse particle size distribution (average 5 µm) guarantees uniform reactivity and consistent performance across experiments, minimizing variability in results.
High carboxyl group content (~200 µmol/g) provides abundant binding sites for covalent immobilization of peptides, proteins, antibodies, oligonucleotides, and other biological ligands.
Core-shell structure with Fe3O4 magnetic core and polymer shell offers excellent biocompatibility, reducing non-specific binding to biological samples and enhancing the purity of isolated targets.
Preserved in 20% ethanol solution, the beads maintain stability and activity during storage at 2-8°C, with a long shelf life for convenient laboratory use.
Concentrated formulation (10 mg/mL) allows for flexible dilution to meet specific experimental requirements, optimizing cost-effectiveness for various research scales.
Versatile compatibility with multiple research workflows, including immunology detection, molecular biology experiments, and biosensor development.
Exceptional binding efficiency: The high density of carboxyl groups ensures strong and stable covalent conjugation with biological ligands, maximizing the capture efficiency of target molecules (e.g., proteins, nucleic acids).
Easy and time-saving operation: Superparamagnetic properties enable fast magnetic separation, eliminating the need for centrifugation or filtration steps and significantly reducing sample processing time.
Reliable and reproducible results: Monodisperse particles and consistent functional group density minimize experimental variability, ensuring reliable data across repeated experiments and different users.
Broad application scope: Suitable for a wide range of research tasks, from routine protein purification and cell sorting to specialized applications like drug screening and biosensor fabrication, providing versatility for diverse laboratory needs.
Excellent storage stability: The 20% ethanol preservation fluid and recommended storage conditions (2-8°C) maintain bead integrity and activity over time, reducing the risk of product degradation and ensuring long-term usability.
Biocompatible and low background: The polymer shell reduces non-specific interactions with biological samples, improving the signal-to-noise ratio in detection assays and enhancing the purity of isolated targets.
For research use only, not for clinical use.
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