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| Product Name | Mag COOH-SC300 nm |
| Catalog No. | SM-HMM-0007 |
| Description | Silicon dioxide series magnetic microspheres are specially designed for nucleic acid extraction and purification. The surface is silica material, modified with a large number of OH or COOH groups, and can bind to nucleic acids in solution through hydrophobic, hydrogen bonding and electrostatic interaction under high salt and low pH conditions, without binding with other impurities (such as proteins), and quickly separate nucleic acids from biological samples. The operation is safe and simple, which is conducive to the automation and high throughput extraction of nucleic acid. |
| Features | The production process of the magnetic beads is strictly controlled, and each magnetic bead presents a regular spherical shape to ensure the stability of low abundance sample extraction. The surface of the magnetic beads is specialized to achieve DNA/RNA co-extraction. Also suitable for low abundance samples, including free DNA, viral DNA and RNA. Stable production capacity, up to 10kg per month. Batch stable, CV<10% of nucleic acid extraction efficiency in different batches. High throughput and automated operation can be realized, and the fastest extraction can be achieved in 9min with the nucleic acid extractor. |
| Storage | Stable at 2-8°C (can be stored or transported at room temperature for short periods of time) |
| Shelf Life | 2 years |
| Average Particle Size | 300 nm |
| Magnetic Core | Fe3O4 |
| Shell | SiO2 |
| Magnetism Type | Superparamagnetic |
| Saturation Magnetization Strength | 50 emu/g |
| Preservation Fluid | 20% ethanol |
| Concentration | 50 mg/mL |
| Product Introduction | Mag-COOH (sc300 nm) represents an advanced generation of magnetic particles with a sub-300 nanometer diameter and a carboxylated (-COOH) surface. This ultra-small size approaches the dimensions of large proteins or viruses, enabling unique applications. The high surface area and carboxyl groups allow for high-density biomolecule conjugation via EDC/NHS chemistry. Their small size facilitates fast binding kinetics, stable colloidal suspensions ideal for automated platforms, and potential for in vivo diagnostic or therapeutic applications due to enhanced biodistribution properties. |
| Product Application | • Development of high-performance automated chemiluminescent immunoassays (CLIA). • Capture and detection of cell-free DNA (cfDNA) or viral nucleic acids. • In vitro diagnostic (IVD) assay development requiring superior kinetics. • Exploratory research in targeted imaging or drug delivery (as a platform). |
| Product Advantages | • Ultra-Small Size: Provides extremely fast binding kinetics, reduces non-specific binding, and enables stable, non-settling suspensions crucial for homogeneous assays and precise liquid handling in automated systems. • High-Density Carboxyl Groups: Offers a high capacity for covalent conjugation of proteins, peptides, or oligonucleotides, maximizing the density of capture molecules on the bead surface. • Superior Colloidal Stability: The small size and surface charge prevent aggregation, ensuring long-term stability and consistent performance in complex biological matrices. • Platform for Innovation: Suitable for next-generation diagnostic applications, including digital immunoassays, sensitive nucleic acid tests, and exploratory biomedical research. |
For research use only, not for clinical use.
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