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| Product Name | Mag COOH-1 µm |
| Catalog No. | SM-HMM-0013 |
| Description | Polymer-coated magnetic beads have rich functional COOH or NH2 groups, which are capable of covalently immobilizing biological ligands, such as peptides, proteins, antibodies and oligonucleotides. These magnetic beads can be used for immunology detection and molecular biology research. |
| Average Particle Size | 1 µm |
| Surface Group / Content | COOH (~250 µmol/g) |
| Magnetic Core | Fe3O4 |
| Shell | Polymer |
| Magnetism Type | Superparamagnetic |
| Appearance | Monodisperse |
| Preservation Fluid | 20% ethanol |
| Concentration | 10 mg/mL |
| Applications | Protein Purification Immunoassay Cell Sorting Specific Nucleic Acid Isolation Biosensors Drug Screening and Delivery |
In the rapidly evolving landscape of life sciences and molecular biology research, the demand for high-performance tools that enable precise manipulation and isolation of biological targets has never been greater. Magnetic beads have emerged as indispensable assets in laboratories worldwide, revolutionizing workflows across immunology, molecular diagnostics, and biotherapeutics development. Among these, carboxyl-functionalized (COOH) magnetic beads stand out for their versatility and reliability, serving as a critical bridge between biological samples and downstream analytical techniques.
Mag COOH-1 µm is engineered to address the growing need for robust, reproducible, and efficient binding platforms in scientific research. Its development is rooted in the recognition that researchers require tools that combine consistent performance with ease of use—whether for protein purification, nucleic acid isolation, or cell sorting applications.
Key drivers behind the design of this product include:
The need for monodisperse particles to ensure uniform reaction kinetics and minimal batch-to-batch variation, a common pain point in experiments relying on heterogeneous bead populations.
The demand for high surface functional group density, which directly impacts binding capacity and the efficiency of ligand immobilization for sensitive assays.
The requirement for superparamagnetic properties that allow for quick, gentle separation under magnetic fields, preserving the integrity of fragile biological molecules and cells.
The necessity for long-term stability under standard laboratory storage conditions, reducing waste and ensuring product reliability over time.
As research becomes increasingly interdisciplinary, Mag COOH-1 µm is tailored to support a wide range of scientific inquiries—from basic molecular biology studies to advanced biosensor development and drug screening. Its polymer-coated Fe₃O₄ core structure balances magnetic responsiveness with biocompatibility, making it suitable for both in vitro research and specialized applications where sample integrity is paramount.
Precise Particle Size Control: Boasts a uniform average particle size of 1 µm, ensuring consistent diffusion rates, binding efficiencies, and separation behavior across experiments.
High COOH Group Density: Features a surface carboxyl content of approximately 250 µmol/g, providing abundant reactive sites for covalent conjugation with peptides, proteins, antibodies, and oligonucleotides.
Superparamagnetic Performance: Exhibits strong magnetic responsiveness when exposed to an external magnetic field, enabling rapid and complete separation without residual magnetism after field removal.
Monodisperse Appearance: Maintains a homogeneous particle distribution, minimizing aggregation and ensuring even interaction with target analytes for reliable, reproducible results.
Biocompatible Polymer Shell: The polymer coating surrounding the Fe₃O₄ core enhances stability in aqueous and biological buffers, reduces non-specific binding, and protects sensitive ligands from degradation.
Convenient Preservation: Supplied in 20% ethanol preservation fluid, ensuring long-term stability at 2–8°C and eliminating the need for complex pre-use preparation.
Optimized Concentration: Formulated at 10 mg/mL, a standard concentration that balances reagent economy with sufficient binding capacity for most research-scale applications.
Enhanced Binding Efficiency: The high density of COOH groups facilitates robust covalent immobilization of biological ligands, maximizing target capture and improving the sensitivity of downstream assays.
Preserved Sample Integrity: Gentle magnetic separation enabled by superparamagnetism minimizes mechanical stress on proteins, nucleic acids, and cells, ensuring their structural and functional integrity for subsequent analysis.
Reduced Experimental Variability: Monodisperse particles and strict quality control standards result in minimal batch-to-batch variation, enhancing the reproducibility of experimental data.
Broad Compatibility: Compatible with a wide range of buffers, conjugation chemistries (e.g., EDC/NHS coupling), and downstream techniques (e.g., ELISA, PCR, flow cytometry), supporting versatile experimental design.
Easy Integration into Workflows: Requires no specialized equipment beyond a standard magnetic separator, allowing for seamless incorporation into existing laboratory protocols without additional investment.
Long-Term Stability: Maintains performance and structural integrity when stored at 2–8°C, reducing the need for frequent reagent replacement and minimizing research downtime.
Low Non-Specific Binding: The polymer shell is engineered to reduce unwanted interactions with non-target molecules, improving the signal-to-noise ratio in assays and simplifying sample purification.
For research use only, not for clinical use.
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