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| Product Name | Zinquin Ethyl Ester (Cell-Permeant Zinc Fluorescent Probe) |
| Catalog No. | RESK-0525 |
| Description | Zinquin ethyl ester is a lipophilic, cell-membrane-permeant fluorescent probe for zinc ions. Intracellular esterases in living cells hydrolyze the ethyl ester group to generate Zinquin, which is retained inside the cell and prevented from leaking back across the membrane. Zinquin forms a complex with Zn2+ at the nitrogen atom of its structure. Zinquin is excited by UV light and fluoresces in the blue spectral range (excitation 368 nm, emission 490 nm). It can also be used to monitor apoptosis-associated changes in intracellular Zn2+ flux. |
| Intended Use | Fluorescent detection and imaging of intracellular zinc ions in living cells, including monitoring of apoptosis-related intracellular Zn2+ flux. For research use only. |
| Principle / Technology | The lipophilic ethyl ester crosses the cell membrane and is hydrolyzed by intracellular esterases to Zinquin, trapping the probe inside the cell. Zinquin chelates Zn2+ via its nitrogen atom and emits blue fluorescence upon UV excitation. |
| Detection Method | Fluorescence imaging / fluorescence measurement (UV excitation, blue emission) |
| Sample Type | Living cultured cells |
| Performance Range / Specifications | Appearance: powder CAS NO.: 181530-09-6 Formula: C21H22N2O5S Molecular weight: 414.4 Ex/Em: 335/491 nm (product specification); UV excitation at 368 nm and blue emission at 490 nm reported for Zinquin-Zn2+ fluorescence Solubility: soluble in DMSO |
| Specificity | Forms a fluorescent complex with Zn2+ at the nitrogen atom of the Zinquin structure. |
| Storage Conditions | Store at -25 to -15°C, protected from light. |
| Shelf Life | One year when stored as recommended. |
| Package Specifications | 1 mg 5 mg |
| Product Form | Powder |
| Molecular Weight | 414.4 |
| Expiration Date / Stability | Stable for one year at -25 to -15°C protected from light. |
| Regulatory / Compliance | For research use only. |
| Recommended Buffer System | Stock solutions prepared in DMSO. |
| Application Notes / Precautions | Intracellular esterases convert the probe to Zinquin, retaining it within living cells. Suitable for monitoring apoptosis-associated intracellular Zn2+ flux changes. Protect from light. |
For research use only, not for clinical use.
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