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| Product Name | Recombinant Human C-C Chemokine Receptor Type 8 (CCR8), Full Length, VLP, Active |
| Catalog No. | PTR-HMM-0253 |
| Description | A full-length recombinant human CCR8 membrane protein produced in mammalian cells and presented in a virus-like particle format. VLP-like structures were confirmed by TEM, and antibody-binding activity was verified by functional ELISA and BLI. |
| Intended Use | Suitable for antibody-binding studies, chemokine receptor research, tumor immunology research, VLP immunogenicity studies, and assay development. |
| Principle / Technology | A defined recombinant protein region is expressed and purified, then its structural quality and biological function are evaluated using the listed biochemical binding or activity assays. |
| Detection Method | SEC-HPLC; functional ELISA; TEM; BLI; Western blot; LAL assay |
| Sample Type | Purified recombinant protein |
| Performance Range / Specifications | Purity: >=90% by SEC-HPLC.. Molecular weight: 42.2 kDa. Package sizes: 20 ug; 100 ug; 1 mg. |
| Sensitivity / LOD | In a functional ELISA, immobilized human CCR8 at 5 ug/mL bound a CCR8-specific recombinant antibody with an EC50 of 11.13-17.29 ng/mL. BLI analysis measured an affinity constant below 1 pM with a CCR8-specific antibody. |
| Specificity | Binding activity was demonstrated with a CCR8-specific recombinant antibody. |
| Reaction Conditions / Protocol | In a functional ELISA, immobilized human CCR8 at 5 ug/mL bound a CCR8-specific recombinant antibody with an EC50 of 11.13-17.29 ng/mL. BLI analysis measured an affinity constant below 1 pM with a CCR8-specific antibody. |
| Components / Formulation | PBS, 6% trehalose, pH 7.4 |
| Storage Conditions | Store at -20 C or -80 C upon receipt. Aliquot before repeated use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Typical stability is 6 months for liquid material and 12 months for lyophilized material when stored at -20 C or -80 C. |
| Package Specifications | 20 ug; 100 ug; 1 mg |
| Product Form | Liquid |
| Quality Control | Purity evaluated by sec-hplc; endotoxin tested by lal assay; biological activity verified by functional elisa; particle morphology confirmed by tem; binding affinity evaluated by bli. |
| Key Features | Active full-length human CCR8; VLP presentation; C-terminal 10xHis tag; mammalian cell expression; particle structure confirmed by TEM. |
| Purity | >=90% by SEC-HPLC. |
| Activity / Unit Definition | In a functional ELISA, immobilized human CCR8 at 5 ug/mL bound a CCR8-specific recombinant antibody with an EC50 of 11.13-17.29 ng/mL. BLI analysis measured an affinity constant below 1 pM with a CCR8-specific antibody. |
| Molecular Weight | 42.2 kDa |
| Source / Origin | Human protein produced in Mammalian cells. |
| pH Range / Optimal pH | pH 7.4 |
| Expiration Date / Stability | Typical stability is 6 months for liquid material and 12 months for lyophilized material when stored at -20 C or -80 C. |
| Regulatory / Compliance | For research use only; not for clinical diagnosis or treatment. |
| Compatibility | Suitable for antibody-binding studies, chemokine receptor research, tumor immunology research, VLP immunogenicity studies, and assay development. |
| Recommended Buffer System | PBS, 6% trehalose, pH 7.4 |
| Application Notes / Precautions | Briefly centrifuge the vial before opening. Reconstitute with sterile deionized water to 0.1-1.0 mg/mL when applicable. For long-term storage, add 5-50% glycerol as appropriate, divide into aliquots, and freeze. Avoid repeated freezing and thawing. A working aliquot may be kept at 4 C for up to one week. |
| Alternative Names / Synonyms | CCR8; CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CHEMR1; GPRCY6; TER1; CDw198 |
| Lead Time | 3-7 business days |
| Availability Status | In Stock |
| Host Species | Human |
| Tag Information | C-terminal 10xHis tag, detectable under denaturing conditions |
| Amino Acid Sequence | MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL |
| UniProt Accession | P51685 |
| Protein Length | 355 aa |
| Expression Region | 1-355 aa |
| Endotoxin Level | <1.0 EU/ug by the LAL method. |
For research use only, not for clinical use.
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