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| Product Name | Pro-Gastrin-Releasing Peptide (ProGRP) CLIA Kit |
| Catalog No. | TMTR-HMM-0061 |
| Description | A chemiluminescence immunoassay kit for the quantitative determination of ProGRP in serum, providing a highly specific tumor marker for small cell lung cancer with superior discriminatory power compared to NSE. |
| Intended Use | Quantitative ProGRP measurement in serum as a biomarker for small cell lung cancer diagnosis, differential diagnosis from benign pulmonary conditions, and post-treatment monitoring. |
| Principle / Technology | One-step sandwich CLIA with monoclonal antibodies against distinct epitopes on the ProGRP (31-98) peptide. |
| Detection Method | Automated chemiluminescence detection |
| Sample Type | Human serum; samples should be centrifuged promptly after clotting and assayed or frozen within 4 hours |
| Performance Range / Specifications | 3.0–5000 pg/mL analytical measurement range |
| Sensitivity / LOD | ≤1.5 pg/mL limit of detection |
| Specificity | High specificity for ProGRP (31-98); no detectable cross-reactivity with GRP, bombesin, or neuromedin B at concentrations up to 10,000 pg/mL |
| Reaction Conditions / Protocol | Automated 20-minute one-step incubation of sample with microparticle reagent and labeled antibody, followed by magnetic separation and signal measurement |
| Components / Formulation | Paramagnetic microparticles coated with anti-ProGRP antibody, acridinium ester-labeled detection antibody, reaction buffer, ProGRP calibrator set, ProGRP controls |
| Storage Conditions | 2–8°C; calibrators should be handled gently to prevent foaming which may affect concentration accuracy |
| Shelf Life | 18 months |
| Package Specifications | 100 tests |
| Product Form | Ready-to-use liquid reagents |
| Quality Control | Calibrators traceable to manufacturer reference standard; inter-assay CV below 4%; 95th percentile reference value below 50 pg/mL in healthy individuals |
| Key Features | Superior specificity for SCLC versus NSE due to minimal release from hemolyzed erythrocytes; serum stability at room temperature for up to 24 hours; integrated automated workflow suitable for high-volume clinical laboratories |
For research use only, not for clinical use.
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