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| Product Name | Glutamic-oxalacetic Transaminase (GOT) Activity Assay Kit, 50T/24S |
| Catalog No. | AACAK-YJL-0029 |
| Detection Method | Visible spectrophotometry, Spectrophotometer |
| Storage | Store at 2-8°C, 6 months |
| Intended Use | For research use only. |
| Note | For your safety and health, please wear lab coat, disposable gloves and mask during operation. |
| Product Introduction | Glutamic-oxalacetic transaminase (GOT), also known as aspartate aminotransferase (AST), catalyzes the reversible transfer of an amino group between aspartate and α-ketoglutarate, forming oxaloacetate and glutamate. AST is present in high concentrations in heart and liver mitochondria and cytosol, and in skeletal muscle. Its release into circulation indicates damage to these tissues, making it a key diagnostic marker alongside ALT. This kit measures AST activity kinetically by coupling the oxaloacetate produced to the oxidation of NADH via malate dehydrogenase (MDH). |
| Product Application | • Clinical diagnosis and monitoring of liver diseases (hepatitis, cirrhosis). • Assessment of myocardial infarction (heart attack) and cardiac injury. • Research on muscle disorders and rhabdomyolysis. • Preclinical safety assessment in drug development (cardiotoxicity, hepatotoxicity). |
| Product Advantages | • IFCC-Recommended Method: Based on the optimized kinetic assay recommended by the International Federation of Clinical Chemistry (IFCC), ensuring standardized, reliable results. • Dual-Compartment Information: While less liver-specific than ALT, elevated AST can provide clues about mitochondrial involvement (higher mitochondrial isoform release) in injury. • High Correlation with Clinical Analyzers: The assay performance is calibrated to match results from automated clinical chemistry systems, facilitating translational research. • Minimal Sample Requirement: Requires a small volume of serum or plasma, making it suitable for studies with limited sample availability, including rodent models. |
For research use only, not for clinical use.
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