- Home
- IVD
- By Technology Types
- By Diseases Types
- By Product Types
- Research
- Resource
- Distributors
- Company
| Product Name | Proline Dehydrogenase (ProDH) Activity Assay Kit, 50T/48S |
| Catalog No. | AACAK-YJL-0013 |
| Detection Method | Visible spectrophotometry, Spectrophotometer |
| Storage | Store at -20°C, 6 months |
| Intended Use | For research use only. |
| Note | For your safety and health, please wear lab coat, disposable gloves and mask during operation. |
| Product Introduction | Proline dehydrogenase (PRODH), the first enzyme in the proline catabolism pathway, catalyzes the oxidation of proline to Δ¹-pyrroline-5-carboxylate (P5C) in the mitochondria. This reaction is crucial for energy production during stress, redox homeostasis (transferring reducing equivalents to the electron transport chain), and providing precursors for biosynthesis. Dysregulation of PRODH is linked to cancer, neurological disorders, and metabolic diseases. This kit measures PRODH activity by coupling the reduction of an electron acceptor to a colorimetric change. |
| Product Application | • Studies of cellular adaptation to osmotic, oxidative, or nutrient stress. • Research on cancer metabolism, particularly in tumors utilizing proline as a fuel source. • Investigation of neurological conditions and psychiatric disorders linked to proline metabolism. • Plant biology studies on stress tolerance and nitrogen recycling. |
| Product Advantages | • Mitochondrial Enzyme Focus: Specifically optimized to measure the activity of the mitochondrial PRODH isoform, the key enzyme in energy-generating proline catabolism. • Coupled Spectrophotometric Assay: Employs a robust enzymatic or chemical coupling system to generate a measurable signal proportional to PRODH activity. • Suitable for Tissue Homogenates: Validated for use with mitochondrial extracts and crude tissue lysates, accommodating complex biological samples. • Enables Kinetic Studies: The continuous assay format allows for real-time monitoring of reaction rates, facilitating inhibitor studies and kinetic characterization. |
For research use only, not for clinical use.
|
There is no product in your cart. |
Copyright © 2026 Alta DiagenoTech. All rights reserved.