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| Product Name | Succinate Dehydrogenase (SDH) Activity Assay Kit, 50T/48S |
| Catalog No. | SCAK-YJL-0043 |
| Detection Method | Visible spectrophotometry, Spectrophotometer |
| Storage | Store at -20°C, 6 months |
| Intended Use | For research use only. |
| Note | For your safety and health, please wear lab coat, disposable gloves and mask during operation. |
| Product Introduction | Succinate dehydrogenase (SDH), or Complex II of the mitochondrial electron transport chain (ETC), is a unique enzyme that participates in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate, transferring electrons to ubiquinone. Its activity is a direct indicator of mitochondrial integrity and function. This kit measures SDH activity by tracking the reduction of a water-soluble electron acceptor, which is coupled to a colorimetric probe, providing a sensitive readout suitable for tissue homogenates and isolated mitochondria. |
| Product Application | • Assessment of mitochondrial function and bioenergetic capacity in cells and tissues. • Research on mitochondrial disorders, neurodegenerative diseases, and ischemia-reperfusion injury. • Toxicology studies evaluating drug or chemical-induced mitochondrial dysfunction. • Investigation of the role of SDH mutations (e.g., in paragangliomas) or its role in metabolic signaling. |
| Product Advantages | • Mitochondrial-Specific: Assay conditions are optimized to reflect the activity of the intact mitochondrial complex, minimizing non-specific signals. • No Interference from NADH: The assay is independent of NADH/NAD+ redox status, allowing clear isolation of Complex II activity. • Sensitive Detection: Can detect activity changes in small sample amounts, such as biopsy specimens or primary cell cultures. • Functional Insight: Provides a direct measure of a key enzymatic step linking metabolism to energy production. |
For research use only, not for clinical use.
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