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| Product Name | Recombinant Human C-C Chemokine Receptor Type 4 (CCR4), Full Length, Active |
| Catalog No. | PTR-HMM-0130 |
| Description | An active recombinant human CCR4 protein representing full length, produced using In vitro E. coli expression system and purified for functional protein research. |
| Intended Use | For protein interaction studies, antibody evaluation, assay development, functional characterization and related life-science research. |
| Principle / Technology | Recombinant expression using In vitro E. coli expression system, followed by purification and functional qualification. |
| Detection Method | ELISA binding assay; SPR; MetaSPR |
| Sample Type | Purified recombinant protein |
| Performance Range / Specifications | Package options: 20 ug; 100 ug. Purity: >=85% by SDS-PAGE. Functional performance: Functional ELISA gives an anti-CCR4 antibody EC50 of 2.803-3.369 ng/mL. SPR measurements show binding affinities of 3.16 nM and 1.71 nM in forward and reverse assay orientations, respectively. |
| Sensitivity / LOD | ELISA EC50: 2.803-3.369 ng/mL; SPR KD: 3.16 nM; reverse MetaSPR KD: 1.71 nM |
| Specificity | Human CCR4 |
| Reaction Conditions / Protocol | Functional ELISA gives an anti-CCR4 antibody EC50 of 2.803-3.369 ng/mL. SPR measurements show binding affinities of 3.16 nM and 1.71 nM in forward and reverse assay orientations, respectively. |
| Components / Formulation | PBS containing 0.05% FOS-12 and 6% trehalose, pH 8.0 |
| Storage Conditions | Store at -20 C or -80 C. Prepare working aliquots for repeated use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Liquid: 6 months at -20 C or -80 C. Lyophilized: 12 months at -20 C or -80 C. |
| Package Specifications | 20 ug; 100 ug |
| Product Form | Lyophilized powder |
| Quality Control | Purity is assessed by the method stated in the specification. Functional performance is qualified by elisa binding assay; spr; metaspr. |
| Key Features | Active recombinant human CCR4; Full length; In vitro E. coli expression system; >=85% by SDS-PAGE purity; documented functional performance. |
| Purity | >=85% by SDS-PAGE |
| Activity / Unit Definition | Functional ELISA gives an anti-CCR4 antibody EC50 of 2.803-3.369 ng/mL. SPR measurements show binding affinities of 3.16 nM and 1.71 nM in forward and reverse assay orientations, respectively. |
| Molecular Weight | 44.2 kDa |
| Source / Origin | Human; recombinant production using In vitro E. coli expression system. |
| pH Range / Optimal pH | 8.0 |
| Expiration Date / Stability | Liquid material is stable for 6 months at -20 C or -80 C; lyophilized material is stable for 12 months at -20 C or -80 C. |
| Regulatory / Compliance | For research use only; not for clinical diagnosis or treatment. |
| Compatibility | ELISA; SPR; MetaSPR; membrane-protein binding studies |
| Recommended Buffer System | PBS containing 0.05% FOS-12 and 6% trehalose, pH 8.0 |
| Application Notes / Precautions | Briefly centrifuge lyophilized material before opening. Reconstitute with sterile deionized water to 0.1-1.0 mg/mL. For extended storage after reconstitution, add glycerol to a final concentration of 5%-50%, prepare working aliquots and avoid repeated freeze-thaw cycles. Working aliquots may be kept at 4 C for up to one week. |
| Alternative Names / Synonyms | C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; K5-5; CD194 |
| Lead Time | 3-7 working days |
| Availability Status | In Stock |
| Host Species | Human |
| Tag Information | N-terminal 10xHis-tagged |
| Amino Acid Sequence | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL |
| UniProt Accession | P51679 |
| Protein Length | 360 aa |
| Expression Region | 1-360 aa |
For research use only, not for clinical use.
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