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| Product Name | Human CORT (Corticosterone) ELISA Kit |
| Catalog No. | HTK-YJL-0238 |
| Synonyms | Corticosterone ELISA Kit, CORT ELISA Kit |
| Species | Human |
| Sample Type | Serum, plasma, cell culture supernatant, cell or tissue lysate, other liquid samples |
| Detection Method | Competitive ELISA, Coated with Antigen |
| Detection Wavelength | OD450 |
| Reaction Duration | 2 hours |
| Range | 2.813-180 ng/ml |
| Sensitivity | 1.688 ng/ml |
| Storage | 2-8°C (Sealed). Don't cryopreserve. |
| Specificity | Specifically binds with CORT, no obvious cross reaction with other analogues. |
| Intended Use | For research use only. |
Corticosterone, the target analyte detected by this ELISA kit, is a critical adrenal steroid and serves as a major glucocorticoid in humans. Synthesized primarily in the adrenal cortex, it plays pivotal roles in regulating multiple physiological processes, including metabolism, immune response modulation, and stress adaptation. Beyond the adrenal cortex, recent research has identified the presence of enzymes involved in corticosterone synthesis in various other cells and tissues—such as the heart—expanding understanding of its localized biological functions.The biological effects of corticosterone are mediated through two key types of receptors: cytoplasmic mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs). These receptors act as ligand-inducible transcription factors, meaning they activate or repress gene expression upon binding to corticosterone, thereby exerting widespread impacts on cellular function.Notably, corticosterone has profound implications for neuroscience research. It strongly influences the structure and function of the hippocampus, a brain region critical for memory formation and spatial learning. Studies suggest that corticosterone action via glucocorticoid receptors in the brain may be closely linked to memory storage processes. Additionally, emotional or physiological stress is a well-documented trigger for increased plasma corticosterone levels, making the accurate quantification of this hormone essential for research into stress-related disorders, neurobiology, metabolism, and cardiovascular health.This Human CORT (Corticosterone) ELISA Kit is specifically designed to support such research by enabling precise, reliable measurement of corticosterone in biological samples. It is intended for research use only, not for clinical use, ensuring it meets the specialized needs of academic laboratories, pharmaceutical research teams, and biotech organizations investigating corticosterone-associated biological mechanisms.
Target-specific detection: The kit specifically binds to human corticosterone, with no obvious cross-reactivity with other structural analogues, ensuring accurate differentiation of the target analyte from interfering substances in samples.
Versatile sample compatibility: It is validated for use with multiple common biological sample types, including serum, plasma, cell culture supernatant, cell lysate, and tissue lysate, as well as other liquid samples, accommodating diverse research experimental designs.
Clear detection wavelength: Operates at a standard OD450 nm wavelength, which is widely compatible with most microplate readers commonly available in research laboratories, eliminating the need for specialized equipment.
Moderate reaction duration: The total assay time is 2 hours, balancing efficiency and detection performance—allowing researchers to process multiple samples within a single workday without compromising data reliability.
Well-defined detection range: Covers a range of 2.813–180 ng/ml, which aligns with the typical concentration of corticosterone in human biological samples, ensuring most research samples can be measured without excessive dilution or concentration steps.
Reliable sensitivity: Boasts a sensitivity of 1.688 ng/ml, enabling the detection of low levels of corticosterone in samples, which is critical for studies investigating subtle changes in hormone levels (e.g., stress response kinetics or early-stage metabolic perturbations).
Stable storage conditions: Requires storage at 2–8°C (sealed) and no cryopreservation, simplifying inventory management and reducing the risk of reagent degradation due to improper freezing/thawing cycles.
High specificity minimizes data interference: The absence of significant cross-reactivity with analogues ensures that measured values accurately reflect the actual concentration of corticosterone in samples, reducing the likelihood of false positives or misleading results that could compromise research outcomes.
Broad sample applicability enhances experimental flexibility: Compatibility with multiple sample types means researchers do not need to purchase separate kits for different sample sources (e.g., comparing serum corticosterone levels with those in cell culture supernatant), saving time and research costs.
Time-efficient assay workflow: A 2-hour total reaction duration allows for high-throughput sample processing, which is particularly beneficial for laboratories handling large sample batches (e.g., cohort studies or drug screening experiments).
Optimal detection range and sensitivity: The combination of a 2.813–180 ng/ml range and 1.688 ng/ml sensitivity ensures the kit can detect both physiological baseline levels and stress-induced elevated levels of corticosterone, meeting the needs of various research scenarios.
Easy storage and handling: Storage at 2–8°C (no cryopreservation) reduces the complexity of reagent maintenance, making the kit accessible even for laboratories with limited specialized storage equipment (e.g., -80°C freezers).
For research use only, not for clinical use.
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