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| Product Name | Rat Drd2 (D (2) Dopamine Receptor) ELISA Kit |
| Catalog No. | HTK-YJL-0052 |
| Synonyms | D(2) Dopamine Receptor ELISA Kit, Dopamine D2 Receptor ELISA Kit, DRD2 ELISA Kit |
| Species | Rat |
| UniProt ID | P61169 |
| Sample Type | Serum, plasma, cell culture supernatant, cell or tissue lysate, other liquid samples |
| Detection Method | Sandwich ELISA, Double Antibody |
| Detection Wavelength | OD450 |
| Reaction Duration | 4 hours |
| Range | 1.563-100 mIU/ml |
| Sensitivity | 0.938 mIU/ml |
| Storage | 2-8°C (Sealed). Don't cryopreserve. |
| Specificity | Specifically binds with Drd2, no obvious cross reaction with other analogues. |
| Intended Use | For research use only. |
The Rat Drd2 (D (2) Dopamine Receptor) ELISA Kit is designed for the quantitative detection of the D2 Dopamine Receptor (Drd2) in rat-derived samples, a key target in neuroscience and signal transduction research. Drd2 is a G protein-coupled receptor (GPCR) that plays a critical role in regulating dopamine neurotransmission, which is closely associated with various physiological processes and pathological conditions—including reward mechanisms, motor control, mood regulation, and neurological disorders like Parkinson’s disease and schizophrenia.Two major isoforms of Drd2 exist: the short isoform (D2sh) and the long isoform (D2lh). The D2sh isoform is primarily localized presynaptically and functions as an autoreceptor, modulating dopamine neurotransmission through feedback mechanisms (e.g., regulating the synthesis, storage, and release of dopamine into the synaptic cleft). In contrast, the D2lh isoform is mainly postsynaptic and exerts classic receptor functions, mediating excitatory or inhibitory neurotransmission when activated by endogenous dopamine, synthetic agonists, or blocked by antagonists.Drd2 activation is coupled to the Gαi protein, which subsequently enhances phosphodiesterase activity. This enzyme breaks down cyclic adenosine monophosphate (cAMP), leading to an inhibitory effect on neuronal activity—making Drd2 a vital target for studying signal transduction pathways in neuroscience, as well as related fields like cancer research (where abnormal dopamine signaling may influence cell proliferation and survival).
Species-specificity: Specifically designed for detecting Drd2 in rat samples (Rattus norvegicus), with no obvious cross-reactivity with Drd2 analogues or non-target proteins.
Broad sample compatibility: Suitable for analyzing multiple sample types, including serum, plasma, cell culture supernatants, cell lysates, tissue lysates, and other liquid biological fluids.
Reliable detection method: Adopts the double-antibody sandwich ELISA technique, a well-established and highly specific immunoassay method that ensures accurate binding and quantification of target Drd2.
Defined detection parameters: Offers a clear detection range of 1.563–100 mIU/ml and high sensitivity of 0.938 mIU/ml, enabling the detection of both low and moderate concentrations of Drd2 in samples.
Convenient storage conditions: Can be stored at 2–8°C (sealed) for short-term use; cryopreservation is not required, simplifying inventory management and reducing storage-related risks.
Research-only focus: Explicitly intended for research applications, aligning with standard laboratory workflows in neuroscience, signal transduction, and related life science research areas.
High specificity: Eliminates the risk of false positive/negative results by avoiding cross-reactivity with non-target molecules, ensuring reliable data for research experiments.
Sufficient sensitivity: The low detection limit (0.938 mIU/ml) allows for the quantification of low-abundance Drd2 in samples, which is critical for studies where Drd2 expression levels are low (e.g., certain tissue types or experimental conditions).
Versatile sample use: Supports a wide range of common laboratory sample types, reducing the need for specialized sample preparation or additional kits for different sample sources, thus saving time and research costs.
Streamlined experimental workflow: Requires a total reaction duration of 4 hours, balancing efficiency and assay performance—allowing researchers to complete experiments within a single workday.
Stable storage: Short-term storage at 2–8°C (no cryopreservation needed) maintains kit performance, reducing the likelihood of reagent degradation and ensuring consistent results across batches.
Well-documented target information: Target Drd2 is associated with a known UniProt ID (P61169), facilitating cross-referencing with existing databases (e.g., protein sequence, structure, and function data) to support experimental design and data interpretation.
For research use only, not for clinical use.
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