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| Product Name | Rat C-P (C-Peptide) ELISA Kit |
| Catalog No. | HTK-YJL-0104 |
| Synonyms | C-P ELISA Kit, C Peptide ELISA Kit |
| Species | Rat |
| UniProt ID | P01322 |
| Sample Type | Serum, plasma, cell culture supernatant, cell or tissue lysate, other liquid samples |
| Detection Method | Sandwich ELISA, Double Antibody |
| Detection Wavelength | OD450 |
| Reaction Duration | 4 hours |
| Range | 78.125-5000 pg/ml |
| Sensitivity | 46.875 pg/ml |
| Storage | 2-8°C (Sealed). Don't cryopreserve. |
| Specificity | Specifically binds with C-P, no obvious cross reaction with other analogues. |
| Intended Use | For research use only. |
C-Peptide (Connecting Peptide) is a 31-amino acid polypeptide that plays a critical role in the biosynthesis of insulin. It is cleaved from proinsulin during processing in pancreatic β-cells, with one molecule of C-Peptide released alongside one molecule of insulin into the bloodstream. Unlike insulin, C-Peptide is not metabolized by the liver to a significant extent, making it a reliable biomarker for assessing endogenous insulin secretion—this is particularly valuable in research studies focused on diabetes, pancreatic function, and metabolic disorders.
In research contexts, measuring rat C-Peptide levels is widely used to investigate the pathogenesis of type 1 and type 2 diabetes in rodent models. For example, it helps researchers evaluate the impact of experimental treatments (e.g., drugs, dietary interventions, or gene therapies) on pancreatic β-cell function, as reduced C-Peptide levels often indicate β-cell dysfunction or loss.
Additionally, recent studies have revealed that C-Peptide itself exhibits biological activity beyond its role as an insulin biosynthesis byproduct. It has been shown to modulate 微血管 blood flow, support tissue repair, and interact with receptors on neurons, endothelial cells, and renal tubular cells—opening up research avenues in fields like neurobiology, cardiovascular physiology, and nephrology.
The Rat C-P (C-Peptide) ELISA Kit is designed to quantify C-Peptide levels in common rat biological samples, providing researchers with a precise tool to advance studies in endocrinology, metabolism, and related disease models.
Species-specific detection: Specifically targets rat C-Peptide (UniProt ID: P01322) with no obvious cross-reactivity with C-Peptide analogs or other related peptides, ensuring accurate results for rat-focused research.
Versatile sample compatibility: Suitable for analyzing multiple rat sample types, including serum, plasma, cell culture supernatant, cell lysates, and tissue lysates—accommodating diverse research designs (e.g., in vitro cell experiments, in vivo animal studies).
Reliable detection method: Utilizes the sandwich ELISA (double antibody) technique, a well-established and highly specific immunoassay format that minimizes non-specific binding and enhances result reproducibility.
Clear detection wavelength: Operates at OD450 nm, a standard wavelength for ELISA readers, ensuring compatibility with most laboratory equipment and simplifying experimental workflows.
Defined performance ranges: Offers a detection range of 78.125–5000 pg/ml and a sensitivity of 46.875 pg/ml, covering the typical C-Peptide concentration range in rat biological samples and enabling detection of both low and high expression levels.
Convenient storage conditions: Requires storage at 2–8°C (sealed) and no cryopreservation, reducing the risk of reagent degradation and simplifying laboratory inventory management.
Time-efficient workflow: Features a total reaction duration of 4 hours, allowing researchers to complete assays within a single workday and streamline experimental timelines.
High specificity: Eliminates interference from non-target molecules (e.g., insulin, proinsulin, or other peptides), ensuring that measured values accurately reflect rat C-Peptide concentrations—critical for reliable data interpretation in research.
Broad sample applicability: Supports analysis of various sample types without the need for specialized pre-treatment (beyond standard sample preparation steps like centrifugation or lysis), reducing experimental complexity and expanding its utility across different study designs.
Consistent performance: The sandwich ELISA format delivers low intra-assay and inter-assay variability (aligned with industry standards for ELISA kits), ensuring that results are reproducible across experiments and between different users.
User-friendly operation: Does not require advanced technical expertise or specialized equipment beyond a standard ELISA reader, making it accessible to researchers with varying levels of immunoassay experience.
Stable reagent storage: Storage at 2–8°C (no cryopreservation) maintains reagent activity over time, reducing waste from expired or degraded components and ensuring long-term usability.
Research-focused design: Tailored to the needs of rat model research, providing data that directly supports studies on pancreatic function, diabetes, and metabolic health—aligning with key priorities in endocrinology and translational research.
For research use only, not for clinical use.
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