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| Product Name | Human APOE E2 E3 E4 Genotyping ARMS-qPCR Kit for Six Genotypes |
| Catalog No. | ASNPGDK-0005 |
| Description | The Alta DiagnoTech human APOE genotyping kit detects the E2, E3 and E4 alleles formed by two functional SNPs and resolves all six genotype combinations. APOE variation is associated with differences in statin response and with risk assessment for late-onset Alzheimer's disease. |
| Intended Use | APOE genotyping to provide reference information for hyperlipidemia, coronary heart disease and Alzheimer's disease assessment, and to support individualized statin use. |
| Principle / Technology | ARMS-PCR genotyping with fluorescent detection and contamination-control chemistry. |
| Detection Method | ARMS-PCR with fluorescent detection |
| Performance Range / Specifications | Six APOE genotypes; minimum detectable genomic DNA concentration 1 ng/µL; maximum tolerated concentration 100 ng/µL; within-run and between-run Ct CV below 5%. |
| Sensitivity / LOD | 1 ng/µL human genomic DNA |
| Specificity | ARMS-PCR is used for high-specificity and high-accuracy genotyping of unknown samples. |
| Components / Formulation | Anti-contamination component. |
| Quality Control | Within-run and between-run Ct coefficient of variation below 5%. |
| Key Features | All six APOE genotype combinations E2, E3 and E4 allele identification 1-100 ng/µL genomic DNA input range Ct precision below 5% CV |
| Product Type | Human gene genotyping kit |
| Analytes / Targets | Human APOE gene |
| Genotypes / Variants Detected | rs429358 (c.388T>C, Cys130Arg) and rs7412 (c.526C>T, Arg176Cys); E2, E3 and E4 alleles and their six genotype combinations. |
For research use only, not for clinical use.
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