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| Product Name | Human AGTR1 (Type-1 Angiotensin II Receptor) ELISA Kit |
| Catalog No. | HTK-YJL-0113 |
| Synonyms | Type-1 Angiotensin II Receptor ELISA Kit, AT1AR ELISA Kit, AT1BR ELISA Kit, Angiotensin II Type-1 Receptor ELISA Kit, AT1 Receptor ELISA Kit, AGTR1 ELISA Kit, AGTR1A ELISA Kit, AGTR1B ELISA Kit, AT2R1 ELISA Kit, AT2R1B ELISA Kit |
| Species | Human |
| UniProt ID | P30556 |
| Sample Type | Serum, plasma, cell culture supernatant, cell or tissue lysate, other liquid samples |
| Detection Method | Sandwich ELISA, Double Antibody |
| Detection Wavelength | OD450 |
| Reaction Duration | 4 hours |
| Range | 0.156-10 ng/ml |
| Sensitivity | 0.094 ng/ml |
| Storage | 2-8°C (Sealed). Don't cryopreserve. |
| Specificity | Specifically binds with AGTR1, no obvious cross reaction with other analogues. |
| Intended Use | For research use only. |
The Human AGTR1 (Type-1 Angiotensin II Receptor) ELISA Kit is a specialized assay tool designed for the quantitative detection of AGTR1, a key protein involved in the renin-angiotensin system (RAS)—a critical regulatory pathway for cardiovascular homeostasis, blood pressure control, and fluid-electrolyte balance. AGTR1, encoded by the AGTR1 gene (UniProt ID: P30556), functions as a G protein-coupled receptor (GPCR) that binds to angiotensin II, triggering downstream signaling cascades linked to vasoconstriction, cell proliferation, and inflammation. Due to its central role in physiological and pathological processes (e.g., hypertension, heart failure, and vascular remodeling), accurate detection of AGTR1 is essential for cardiovascular research, pharmacology studies (e.g., evaluating AGTR1 antagonist drugs), and basic molecular biology investigations.
This ELISA kit leverages the sandwich enzyme-linked immunosorbent assay (double antibody sandwich) principle, a gold-standard technique for specific and sensitive protein quantification in biological samples. It is optimized to detect AGTR1 in a variety of human sample types commonly used in research, including serum, plasma, cell culture supernatants, and cell/tissue lysates—catering to the diverse needs of academic laboratories, pharmaceutical research teams, and biotech institutions. Importantly, this product is for research use only and not for clinical diagnostic procedures, ensuring compliance with research-focused applications.
Target-specific detection: Specifically binds to human AGTR1 with no obvious cross-reactivity with other analogs (e.g., AGTR2 or related GPCRs), ensuring high assay specificity.
Broad sample compatibility: Validated for use with multiple human sample types, including serum, plasma, cell culture supernatant, and cell/tissue lysate, supporting flexible experimental design.
Well-defined detection range: Offers a quantitative range of 0.156–10 ng/ml, covering the typical AGTR1 concentration levels in most biological samples, reducing the need for excessive sample dilution or concentration.
High sensitivity: Achieves a detection limit of 0.094 ng/ml, enabling the quantification of low-abundance AGTR1 in samples with minimal target expression.
Time-efficient workflow: Requires a total reaction duration of 4 hours, balancing assay accuracy with experimental efficiency for high-throughput research needs.
Stable storage conditions: Can be stored at 2–8°C (sealed) without cryopreservation, simplifying inventory management and reducing the risk of reagent degradation.
Reliable performance: The double antibody sandwich method ensures consistent and reproducible results, minimizing intra-assay and inter-assay variability—a critical factor for comparative research studies.
User-friendly protocol: The 4-hour reaction duration and straightforward workflow reduce hands-on time, making the kit accessible to researchers with varying levels of ELISA experience.
No specialized equipment beyond standard lab tools: Operates with a detection wavelength of OD450, which is compatible with most standard microplate readers commonly available in research laboratories, eliminating the need for expensive specialized instruments.
Target relevance to high-impact research areas: Aligns with research in cardiovascular biology, hypertension, pharmacology (e.g., drug development targeting the renin-angiotensin system), and vascular disease, addressing a high-demand niche in life sciences research.
Minimized sample waste: The kit’s design (available in 48T format) accommodates both small-scale experiments (e.g., pilot studies) and moderate-throughput projects, ensuring efficient use of samples and reagents.
For research use only, not for clinical use.
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