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| Product Name | Human GC (Glucagon) ELISA Kit |
| Catalog No. | HTK-YJL-0245 |
| Synonyms | Glicentin ELISA Kit, GC ELISA Kit |
| Species | Human |
| UniProt ID | P01275 |
| Sample Type | Serum, plasma, cell culture supernatant, cell or tissue lysate, other liquid samples |
| Detection Method | Sandwich ELISA, Double Antibody |
| Detection Wavelength | OD450 |
| Reaction Duration | 4 hours |
| Range | 7.813-500 pg/ml |
| Sensitivity | 4.688 pg/ml |
| Storage | 2-8°C (Sealed). Don't cryopreserve. |
| Specificity | Specifically binds with GC, no obvious cross reaction with other analogues. |
| Intended Use | For research use only. |
Glucagon (GC) is a key peptide hormone predominantly secreted by the alpha cells of the pancreatic islets, playing a pivotal role in maintaining glucose homeostasis within the human body. It acts as a physiological antagonist to insulin, stimulating glycogenolysis and gluconeogenesis in the liver to raise blood glucose levels when concentrations drop, ensuring the body’s energy demands are met, especially during fasting or periods of increased metabolic activity.
Beyond its core role in glucose regulation, glucagon is involved in multiple physiological processes, including lipid metabolism (promoting lipolysis in adipose tissue) and protein catabolism. Abnormal expression or function of glucagon has been linked to various metabolic disorders, such as diabetes mellitus (both type 1 and type 2), where disruptions in the insulin-glucagon balance contribute to hyperglycemia. It also serves as a research target for understanding conditions like pancreatic dysfunction, metabolic syndrome, and related complications.
The ability to accurately quantify glucagon levels in biological samples is critical for basic research, preclinical studies, and drug development in the fields of endocrinology, metabolism, and diabetes. ELISA (Enzyme-Linked Immunosorbent Assay) kits have become the gold standard for such quantitative analysis due to their high sensitivity, specificity, and ease of use in laboratory settings. The Human GC (Glucagon) ELISA Kit is specifically designed to meet the demand for reliable detection of human glucagon in various sample types, enabling researchers to gain insights into physiological and pathological mechanisms associated with this hormone.
Target-specific design: Precisely detects human glucagon (GC) with no significant cross-reactivity with other related peptides or analogues, ensuring accurate and reliable assay results.
Versatile sample compatibility: Validated for use with multiple sample types, including serum, plasma, cell culture supernatant, cell or tissue lysate, and other liquid biological samples, providing flexibility for diverse research applications.
Broad dynamic range: Offers a detection range of 7.813-500 pg/ml, covering the physiological and pathological concentration ranges of glucagon in most biological samples, eliminating the need for excessive sample dilution or concentration.
High sensitivity: Boasts a lower limit of detection of 4.688 pg/ml, enabling the quantification of low-abundance glucagon in samples with minimal hormone levels, supporting sensitive research experiments.
Sandwich ELISA technology: Utilizes a double-antibody sandwich method, a well-established and robust technique that enhances assay specificity and signal amplification, ensuring consistent and reproducible results across experiments.
Convenient reaction duration: Completes the entire assay process in 4 hours, balancing efficiency and performance to meet the needs of busy laboratory workflows without compromising data quality.
Stable storage conditions: Requires storage at 2-8°C in a sealed container (no cryopreservation needed), simplifying inventory management and ensuring long-term product stability when stored as recommended.
Reliable performance: Undergoes rigorous quality control during production to ensure batch-to-batch consistency, reducing experimental variability and enhancing the credibility of research data.
User-friendly operation: Comes with a comprehensive datasheet and clear step-by-step instructions, making it suitable for both experienced researchers and laboratory personnel new to ELISA assays, minimizing training time and operational errors.
Cost-effective research tool: Provides accurate and sensitive detection at a competitive value, supporting large-scale experiments or long-term research projects without excessive cost burden.
Time-efficient workflow: The 4-hour total reaction time allows for quick turnaround of results, accelerating research progress and enabling timely data analysis and interpretation.
Wide applicability: Supports a broad range of research areas, including endocrinology, diabetes research, metabolic syndrome studies, pancreatic function research, and drug development targeting glucagon signaling pathways, catering to the diverse needs of the scientific community.
Validated specificity: The absence of obvious cross-reactivity with other analogues ensures that the measured signal directly reflects glucagon concentrations, avoiding false-positive or false-negative results that could compromise research conclusions.
For research use only, not for clinical use.
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